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The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity.细胞周期蛋白依赖性激酶抑制剂氟吡汀对间变性大细胞淋巴瘤细胞的作用及其与NPM-ALK激酶表达和活性的关系。
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Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas.间变性淋巴瘤激酶免疫反应性与非小细胞肺癌中的ALK基因重排及转录上调相关。
Hum Pathol. 2009 Aug;40(8):1152-8. doi: 10.1016/j.humpath.2009.01.012. Epub 2009 Apr 22.
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A phase 1 multidose study of SGN-30 immunotherapy in patients with refractory or recurrent CD30+ hematologic malignancies.一项针对难治性或复发性CD30+血液系统恶性肿瘤患者的SGN-30免疫疗法1期多剂量研究。
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间变性大细胞淋巴瘤：世界卫生组织分类的变化及靶向治疗前景

Anaplastic large cell lymphoma: changes in the World Health Organization classification and perspectives for targeted therapy.

作者信息

Falini Brunangelo, Martelli Maria Paola

出版信息

Haematologica. 2009 Jul;94(7):897-900. doi: 10.3324/haematol.2009.008250.

DOI:10.3324/haematol.2009.008250
PMID:19570751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2704299/
Abstract

The accompanying perspective by Drs. Falini and Martelli provides a clear description of the current WHO classification with a focus on the distinction between ALK-positive anaplastic large cell lymphoma ALCL and ALK-negative disease. Additionally, they provide a rationale for potential new targets for therapy including flavopiridol. See related paper on page 944.

摘要

法利尼博士和马尔泰利博士随附的观点明确描述了世界卫生组织的现行分类，重点在于ALK阳性间变性大细胞淋巴瘤（ALCL）与ALK阴性疾病之间的区别。此外，他们还阐述了包括黄酮哌啶醇在内的潜在新治疗靶点的理论依据。见第944页的相关论文。