1型人类免疫缺陷病毒中的转录错误产生T细胞反应的靶点。
Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses.
作者信息
Garrison Keith E, Champiat Stephane, York Vanessa A, Agrawal Ashish T, Kallas Esper G, Martin Jeffrey N, Hecht Frederick M, Deeks Steven G, Nixon Douglas F
机构信息
Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110, USA.
出版信息
Clin Vaccine Immunol. 2009 Sep;16(9):1369-71. doi: 10.1128/CVI.00410-08. Epub 2009 Jul 1.
Abstract
We measured T-cell responses to human immunodeficiency virus type 1 (HIV-1) cryptic epitopes encoded by regions of the viral genome not normally translated into viral proteins. T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects.
摘要
我们检测了针对人类免疫缺陷病毒1型（HIV-1）隐藏表位的T细胞反应，这些隐藏表位由病毒基因组中通常不翻译成病毒蛋白的区域编码。在HIV-1感染的受试者中检测到了针对隐藏表位以及通常从HIV-1病毒蛋白Rev和Tat中剪接出去的区域的T细胞反应。
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