Samson Sandrine I, Mégard Yves
Sanofi Pasteur MSD, 8 rue Jonas Salk, 69367 Lyon cedex 07, France.
Aging Clin Exp Res. 2009 Jun;21(3):210-5. doi: 10.1007/BF03324912.
Age-related changes in the immune system are associated with increased susceptibility to infections, greater disease severity and poorer outcomes in the elderly compared with young adults. Both influenza and pneumonia are important causes of morbidity and mortality in the elderly, and herpes zoster also represents an important disease burden in this population. Vaccinations against influenza and Streptococcus pneumoniae (pneumococcus) have been shown to reduce the incidence of influenza and invasive pneumococcal disease, respectively, in the elderly. In addition, as is the case with diphtheria/tetanus and herpes zoster vaccines, they can help to reduce the associated burden of disease in vaccinated individuals. Despite the evidence of these benefits, there are considerable variations among the countries of Western Europe in their policies for vaccination in the elderly. Western European countries face the prospect of a population in which the proportion of elderly people is increasing, with a consequent increase in demand on the healthcare system. Acknowledgement of the benefits of vaccination in the elderly, together with comprehensive vaccination policies for this age group, could help to reduce some of these demands.
与年轻人相比,老年人免疫系统的年龄相关变化与感染易感性增加、疾病严重程度更高以及预后较差有关。流感和肺炎都是老年人发病和死亡的重要原因,带状疱疹在这一人群中也构成了重要的疾病负担。已证明,针对流感和肺炎链球菌(肺炎球菌)的疫苗接种分别降低了老年人流感和侵袭性肺炎球菌疾病的发病率。此外,就白喉/破伤风疫苗和带状疱疹疫苗而言,它们有助于减轻接种疫苗个体的相关疾病负担。尽管有这些益处的证据,但西欧各国在老年人疫苗接种政策方面存在很大差异。西欧国家面临着老年人口比例不断上升的前景,这将导致对医疗保健系统的需求增加。认识到老年人疫苗接种的益处,并为这一年龄组制定全面的疫苗接种政策,有助于减少其中一些需求。