Kapur R P, Shaw C M, Shepard T H
Department of Pathology, School of Medicine, University of Washington, Seattle 98195.
Teratology. 1991 Jul;44(1):11-8. doi: 10.1002/tera.1420440104.
Autopsies of 4 fetuses exposed to maternal cocaine are reported. Brain examination revealed hemorrhages in 3 of the fetuses involving the germinal matrix. The hemorrhages resembled subependymal germinal matrix hemorrhages seen as postnatal complications in premature infants with idiopathic respiratory distress syndrome. One of the placentas had sonographic evidence of abruption which could not be confirmed pathologically. The findings are discussed in light of reports of neurobehavioral deficits and other congenital anomalies in children and animals exposed to cocaine in utero. Speculations about the pathophysiologic events leading to these findings are made.
报告了4例暴露于母体可卡因的胎儿的尸检情况。脑部检查发现3例胎儿出现涉及生发基质的出血。这些出血类似于在患有特发性呼吸窘迫综合征的早产儿中作为产后并发症出现的室管膜下生发基质出血。其中一个胎盘有超声显示的胎盘早剥迹象，但病理检查未能证实。根据关于子宫内暴露于可卡因的儿童和动物出现神经行为缺陷及其他先天性异常的报告对这些发现进行了讨论。并对导致这些发现的病理生理事件进行了推测。
