Nagumo A, Takanashi K, Hojo H, Suzuki Y
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Toxicol Lett. 1991 Nov;58(3):309-13. doi: 10.1016/0378-4274(91)90042-5.
To investigate the biological activities of the hopane group of pentacyclic triterpenoids, we isolated one hopanoid, bacteriohopane-32-ol from Rhodopseudomonas palustris and tested its cytotoxicity against mouse leukemia cells in vitro. The IC50 of the hopanoid for L1210 and P388 was 22 and 19 microM respectively. This activity was slightly reduced by co-incubation with cholesterol. As the mechanism of cytotoxic action, disturbances of membrane function and metabolism are discussed.
为了研究五环三萜类化合物藿烷族的生物活性，我们从沼泽红假单胞菌中分离出一种藿烷类化合物——细菌藿烷 - 32 - 醇，并在体外测试了其对小鼠白血病细胞的细胞毒性。该藿烷类化合物对L1210和P388细胞的半数抑制浓度（IC50）分别为22微摩尔和19微摩尔。与胆固醇共同孵育后，这种活性略有降低。作为细胞毒性作用机制，讨论了膜功能和代谢的紊乱情况。
