Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains.
作者信息
Speitling M, Nattewan P, Yazawa K, Mikami Y, Grün-Wollny I, Ritzau M, Laatsch H, Gräfe U
机构信息
Institute of Organic Chemistry, Göttingen, Germany.
出版信息
J Antibiot (Tokyo). 1998 Aug;51(8):693-8. doi: 10.7164/antibiotics.51.693.
PMID:9766460
Abstract
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against P388, L1210 and HeLa tumor cells (IC50; 9.6, >25 and 20 microg/ml, respectively).
摘要
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