肝脏代谢中的己糖激酶和“葡萄糖激酶”
Hexokinase and 'glucokinase' in liver metabolism.
作者信息
Cornish-Bowden A, Cárdenas M L
机构信息
Centre de Biochimie et de Biologie Moléculaire, Centre National de la Recherche Scientifique, Marseille, France.
出版信息
Trends Biochem Sci. 1991 Aug;16(8):281-2. doi: 10.1016/0968-0004(91)90115-c.
PMID:1957348
Abstract
Rat liver contains four hexokinase isoenzymes, one of which, despite often being called 'glucokinase', is no more specific for glucose than the others. However, it does differ from them in displaying a sigmoid kinetic response to glucose, requiring much higher glucose concentrations for activity, and being insensitive to physiological concentrations of glucose 6-phosphate.
摘要
大鼠肝脏含有四种己糖激酶同工酶，其中一种尽管常被称为“葡萄糖激酶”，但对葡萄糖的特异性并不比其他同工酶更高。然而，它与其他同工酶的不同之处在于，它对葡萄糖表现出S形动力学反应，需要更高的葡萄糖浓度才能发挥活性，并且对生理浓度的6-磷酸葡萄糖不敏感。
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