Nod2在克罗恩病发展中的作用。
Role of Nod2 in the development of Crohn's disease.
作者信息
Yamamoto Soichiro, Ma Xiaojing
机构信息
Department of Microbiology and Immunology, Weill Medical College of Cornell University 1300 York Avenue, New York, NY 10021, USA.
出版信息
Microbes Infect. 2009 Oct;11(12):912-8. doi: 10.1016/j.micinf.2009.06.005. Epub 2009 Jun 30.
Abstract
Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process.
摘要
克罗恩病（CD）是由免疫调节功能丧失引起的。Nod2是一种细胞内细菌传感器，其突变与CD的发生发展相关。在此，我们总结了关于Nod2突变体在疾病过程中作用的最新且有争议的研究发现。
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