基于肌动蛋白的突起：癌症侵袭的促进因素还是抑制因素？

Actin-based protrusions: promoters or inhibitors of cancer invasion?

作者信息

Machesky Laura M, Tang Hao Ran

机构信息

The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, Scotland.

出版信息

Cancer Cell. 2009 Jul 7;16(1):5-7. doi: 10.1016/j.ccr.2009.06.009.

DOI:10.1016/j.ccr.2009.06.009

PMID:19573806

Abstract

In a recent issue of Cell, Silva and colleagues reported the identification of CYFIP1, a member of the actin-assembly-promoting Scar/WAVE complex, as an invasion suppressor in epithelial cancers. This study challenges ideas about the role of actin in cancer invasion.

摘要

在最近一期的《细胞》杂志上，席尔瓦及其同事报告称，肌动蛋白组装促进因子Scar/WAVE复合体的成员CYFIP1被鉴定为上皮癌中的一种侵袭抑制因子。这项研究对肌动蛋白在癌症侵袭中作用的观点提出了挑战。