胰腺癌——会有那么简单吗？一个不同的易感性背景。

Pancreatic cancer--could it be that simple? A different context of vulnerability.

作者信息

Von Hoff Daniel D, Korn Ron, Mousses Spyro

机构信息

Translational Genomics Research Institute, Phoenix, AZ 85004, USA.

出版信息

Cancer Cell. 2009 Jul 7;16(1):7-8. doi: 10.1016/j.ccr.2009.06.011.

DOI:10.1016/j.ccr.2009.06.011

PMID:19573807

Abstract

In a recent issue of Science, Olive and colleagues document that inhibition of Hedgehog (Hh) signaling in a genetically engineered mouse model of pancreatic cancer can enhance the intratumor concentration of certain anticancer drugs. Could this finding provide us with a new method to attack pancreatic cancer?

摘要

在最近一期的《科学》杂志上，奥利夫及其同事记录了在胰腺癌基因工程小鼠模型中抑制刺猬信号通路（Hh）可提高某些抗癌药物在肿瘤内的浓度。这一发现能否为我们提供一种治疗胰腺癌的新方法？