Department of Public Health and Epidemiology, Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland.
Trans R Soc Trop Med Hyg. 2009 Dec;103(12):1190-4. doi: 10.1016/j.trstmh.2009.05.012. Epub 2009 Jul 1.
There is a tendency to neglect diagnostic issues in the era of 'preventive chemotherapy' in human helminthiases. However, accurate diagnosis cannot be overemphasized for adequate patient management and monitoring of community-based control programmes. Implicit is a diagnostic dilemma: the more effective interventions are in reducing helminth egg excretion, the less sensitive direct parasitological tests become. Here, experiences gained thus far with the FLOTAC technique for diagnosing common soil-transmitted helminth infections are summarized. A single FLOTAC has higher sensitivity than multiple Kato-Katz thick smears in detecting low-intensity infections. Further validation of the FLOTAC technique in different epidemiological settings is warranted, including diagnosis of intestinal schistosomiasis and food-borne trematodiases.
在人类蠕虫病的“预防化疗”时代,存在忽视诊断问题的倾向。然而,对于适当的患者管理和社区为基础的控制规划的监测,准确的诊断不能被过分强调。这隐含着一个诊断难题:干预措施在减少寄生虫卵排泄方面越有效,直接寄生虫学检测变得越不敏感。这里,总结了迄今为止用 FLOTAC 技术诊断常见土壤传播性蠕虫感染的经验。单次 FLOTAC 比多次加藤厚涂片检测低强度感染的敏感性更高。需要在不同的流行病学环境中进一步验证 FLOTAC 技术,包括肠道血吸虫病和食源性吸虫病的诊断。