Bang B, Heegaard N H
Proteinlaboratoriet, Københavns Universitet.
Ugeskr Laeger. 1991 Nov 25;153(48):3388-92.
Plasma-apheresis is a nonspecific and wasteful intervention requiring the use of potentially infectious and expensive replacement fluids. Selective removal of the unwanted plasma component circumvents most of the problems. For selective binding and removal of plasma components adsorption methods based on the principles of affinity chromatography have been useful. The ideal adsorption column still does not exist, but the number of clinical applications is increasing. The results vary, but the treatment has been used with success in hypercholesterolemia, and in patients with hemophilia with antifactor antibodies and patients with antibodies directed towards HLA-antigens awaiting renal transplantation. In conclusion selective plasma component-apheresis is an improvement in some diseases as compared to conventional plasma-apheresis. The technique is still being improved but large clinical trials examining the effects of plasma-component-apheresis have not yet been published.
血浆置换是一种非特异性且浪费资源的干预措施，需要使用具有潜在传染性且昂贵的置换液。选择性去除不需要的血浆成分可避免大多数问题。基于亲和色谱原理的吸附方法对于选择性结合和去除血浆成分很有用。理想的吸附柱尚未出现，但临床应用的数量正在增加。结果各不相同，但该治疗方法已成功用于高胆固醇血症、患有抗凝血因子抗体的血友病患者以及等待肾移植且有针对HLA抗原抗体的患者。总之，与传统血浆置换相比，选择性血浆成分置换在某些疾病中是一种改进。该技术仍在改进，但尚未发表关于血浆成分置换效果的大型临床试验。
