Moule R, Sohaib A, Eeles R
Radiotherapy Department, University College Hospital, London NW1 2BU, UK.
Clin Oncol (R Coll Radiol). 2009 Aug;21(6):444-7. doi: 10.1016/j.clon.2009.04.004. Epub 2009 Jul 1.
We present a case of dramatic response of poor prognosis cancer in a lady with a germline mutation in the BRCA2 gene who was exposed to platinum containing chemotherapy. She is cancer-free 10 years' later. Such cases provide clinical scenarios for the basis of trials of platinum-like agents in individuals with BRCA mutations who develop cancer.
我们报告了一例患有BRCA2基因种系突变的女性患者，其对含铂化疗有显著反应，该患者患有预后不良的癌症。10年后她已无癌。此类病例为在发生癌症的BRCA突变个体中进行铂类药物试验提供了临床依据。
