生长激素释放激素（GHRH）与促甲状腺激素释放激素（TRH）在肢端肥大症中的相互作用：一项对照研究。

The interaction of GHRH with TRH in acromegaly: a controlled study.

作者信息

Looij B J, Roelfsema F, Frölich M, Nieuwenhuijzen Kruseman A C

机构信息

Department of Endocrinology, University Hospital, Leiden, The Netherlands.

出版信息

Acta Endocrinol (Copenh). 1991 Oct;125(4):337-41. doi: 10.1530/acta.0.1250337.

DOI:10.1530/acta.0.1250337

PMID:1957553

Abstract

In a single-blind placebo-controlled study, the effect of an iv bolus injection of 100 micrograms GHRH(1-29)NH2 on the response to 200 micrograms TRH was assessed in 10 untreated patients with acromegaly to determine whether GHRH interacts with TRH in acromegaly, as previously described in healthy subjects. The combination of GHRH(1-29)NH2 with TRH resulted in a larger increment of peak and of integrated plasma TSH and PRL levels than after TRH alone. GHRH alone had no effect on TSH secretion and only a modest effect on PRL secretion. These findings suggest that in acromegaly, like in healthy individuals, GHRH potentiates the TSH response to TRH and that the effects of GHRH and TRH on PRL secretion are additive.

摘要

在一项单盲安慰剂对照研究中，对10例未经治疗的肢端肥大症患者静脉推注100微克生长激素释放激素（GHRH）（1-29）NH₂后，评估其对200微克促甲状腺激素释放激素（TRH）反应的影响，以确定GHRH在肢端肥大症中是否与TRH相互作用，如同先前在健康受试者中所描述的那样。与单独使用TRH相比，GHRH（1-29）NH₂与TRH联合使用导致血浆促甲状腺激素（TSH）峰值及整合水平和催乳素（PRL）水平有更大幅度的升高。单独使用GHRH对TSH分泌无影响，对PRL分泌仅有适度影响。这些发现表明，在肢端肥大症中，与健康个体一样，GHRH增强了TSH对TRH的反应，并且GHRH和TRH对PRL分泌的作用是相加的。