生长激素释放激素（GHRH）对大鼠体内及体外促甲状腺激素（TSH）释放的影响。
The effect of GHRH on TSH release in rats in vivo and in vitro.
作者信息
Looij B J, Nieuwenhuijzen Kruseman A C, Roelfsema F, van der Heide D, Hoogma R P, Schröder-van der Elst J P
机构信息
Department of Endocrinology, University Hospital, Leiden, The Netherlands.
出版信息
J Endocrinol Invest. 1995 Mar;18(3):214-9. doi: 10.1007/BF03347804.
In man, GHRH has been shown to potentiate the TSH-releasing activity of TRH. To study the way by which GHRH affects TRH-stimulated TSH release, we examined the effect of GHRH (1-29)NH2 on basal and stimulated TSH secretion in intact male rats and superfused dispersed rat pituitary cells. In the intact rats, GHRH(1-29)NH2 potentiated TRH-stimulated TSH release in the evening, but potentiation was not observed in the morning and in dispersed pituitary cells. Basal TSH levels were not changed by GHRH(1-29)NH2. It is concluded that GHRH(1-29)NH2 potentiates the TSH-releasing activity of TRH in the evening in rats possibly through suprahypophyseal disinhibition.
在人类中，生长激素释放激素（GHRH）已被证明可增强促甲状腺激素释放激素（TRH）的促甲状腺激素释放活性。为了研究GHRH影响TRH刺激的促甲状腺激素释放的方式，我们检测了GHRH（1-29）NH2对完整雄性大鼠以及体外灌流的分散大鼠垂体细胞基础和刺激状态下促甲状腺激素分泌的影响。在完整大鼠中，GHRH（1-29）NH2在傍晚增强了TRH刺激的促甲状腺激素释放，但在早晨以及分散的垂体细胞中未观察到这种增强作用。GHRH（1-29）NH2未改变基础促甲状腺激素水平。得出的结论是，GHRH（1-29）NH2可能通过垂体上抑制解除作用在傍晚增强大鼠TRH的促甲状腺激素释放活性。
Zotero 插件