Liu Y, Shi C Z, Zhang J T
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Yao Xue Xue Bao. 1991;26(3):166-70.
Clausenamide is a compound isolated from Clausena lansium (lour) with the structure similar to piracetam. Pharmacological experiments showed that clausenamide po 100-200 mg/kg prolonged both the duration of gasping after decapitation and the survival time after sc NaNO2 225 mg/kg, clausenamide at the concentration of 10(-5) mol/L inhibited the contraction of basilar artery caused by 5-HT, PGF2 alpha and arachidonic acid, indicating that clausenamide is a cerebral protective agent. In addition, multiple doses clausenamide were shown to inhibit the liver lipid peroxidation caused by 50% alcohol and increase the GSH-peroxidase activity significantly in rat liver and brain cytosol.
黄皮酰胺是从黄皮中分离得到的一种化合物，其结构与吡拉西坦相似。药理实验表明，腹腔注射100 - 200mg/kg的黄皮酰胺可延长断头后喘息持续时间以及皮下注射225mg/kg亚硝酸钠后的存活时间，浓度为10(-5)mol/L的黄皮酰胺可抑制5 - HT、PGF2α和花生四烯酸引起的基底动脉收缩，表明黄皮酰胺是一种脑保护剂。此外，多次给药的黄皮酰胺可抑制50%乙醇引起的肝脏脂质过氧化，并显著提高大鼠肝脏和脑细胞溶胶中的谷胱甘肽过氧化物酶活性。
