State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Acta Pharmacol Sin. 2010 Jun;31(6):649-64. doi: 10.1038/aps.2010.46.
With an ageing population, dementia has become one of the world's primary health challenges. However, existing remedies offer limited benefits with certain side effects, which has prompted researchers to seek complementary and alternative therapies. China has long been known for abundant usage of various herbs. Some of these herbal decoctions are effective in stimulating blood circulation, supplementing vital energy and resisting aging, the lack of which are believed to underlie dementia. These herbs are regarded as new and promising sources of potential anti-dementia drugs. With the rapid evolution of life science and technology, numerous active components have been identified that are highly potent and multi-targeted with low toxicity, and therefore meet the requirements for dementia therapy. This review updates the research progress of Chinese herbs in the treatment of dementia, focusing on their effective principles.
随着人口老龄化，痴呆症已成为全球主要的健康挑战之一。然而，现有的治疗方法疗效有限，且伴有一定的副作用，这促使研究人员寻求补充和替代疗法。中国长期以来以广泛使用各种草药而闻名。其中一些草药方剂在促进血液循环、补充元气和抗衰老方面具有一定的效果，据信这些效果的缺乏是导致痴呆症的原因之一。这些草药被视为具有潜在抗痴呆症作用的新型有前途的药物来源。随着生命科学和技术的快速发展，已经鉴定出许多具有高活性和多靶点的低毒性的有效成分，因此符合痴呆症治疗的要求。本文综述了中药治疗痴呆症的研究进展，重点介绍了其有效作用机制。
