Richards T, Goode S D, Hinchliffe R, Altaf N, Macsweeney S, Braithwaite B
University College Hospital, Euston Road, London NW1 2PG, United Kingdom.
Eur J Vasc Endovasc Surg. 2009 Sep;38(3):285-90. doi: 10.1016/j.ejvs.2009.05.018. Epub 2009 Jul 2.
Endovascular repair of aortic aneurysm (EVAR) has a lower mortality than open repair. The aim of this study was to assess mortality from EVAR for emergency AAA repair and the impact of fitness for operation and adverse anatomy.
One-hundred and forty two patients who had EVAR for a ruptured AAA (80, REVAR) or a symptomatic AAA (62, SEVAR) between 1994 and 2007 in a single specialist endovascular centre were reviewed. Fitness for surgery was assessed by Hardman's index (age>76, loss of consciousness, Hb<9.0, Cr>190, ischaemic ECG). CT scans were reviewed, compared with operative images and operation notes for adverse anatomy. Details of perioperative complications, and outcome were recorded.
Overall mortality at 24-h, 30-days and one year were, respectively: 17%, 36%, 50% for REVAR and 5%, 8%, 23% for SEVAR. Overall adverse anatomy increased 30-day mortality. Hardman's index of three or more increased mortality HR=2.59 (1.24-5.41), p=0.01. On Cox regression Univariate analysis increasing Hardman's index score and adverse anatomy increased the overall mortality over time. In multivariate Cox regression analysis (controlled for the Hardman's index) adverse anatomy was associated with significant increase in graft related mortality.
The use of EVAR is feasible in patients who present with a ruptured or acutely symptomatic AAA. Care must be taken not to extend anatomical or clinical guidelines.
腹主动脉瘤的血管内修复术(EVAR)的死亡率低于开放修复术。本研究的目的是评估急诊腹主动脉瘤修复术行EVAR的死亡率以及手术适应性和不良解剖结构的影响。
回顾了1994年至2007年间在一个单一的专业血管内治疗中心接受EVAR治疗破裂性腹主动脉瘤(80例,REVAR)或有症状性腹主动脉瘤(62例,SEVAR)的142例患者。通过哈德曼指数(年龄>76岁、意识丧失、血红蛋白<9.0、肌酐>190、缺血性心电图)评估手术适应性。对CT扫描进行回顾,并与手术图像和手术记录进行比较以确定不良解剖结构。记录围手术期并发症的详细情况和结果。
REVAR组在24小时、30天和1年时的总体死亡率分别为17%、36%、50%;SEVAR组分别为5%、8%、23%。总体不良解剖结构增加了30天死亡率。哈德曼指数为3分或更高时死亡率增加,风险比(HR)=2.59(1.24 - 5.41),p = 0.01。在Cox回归单因素分析中,随着时间推移,哈德曼指数评分增加和不良解剖结构增加了总体死亡率。在多因素Cox回归分析中(控制哈德曼指数),不良解剖结构与移植物相关死亡率的显著增加相关。
对于出现破裂或急性症状性腹主动脉瘤的患者,使用EVAR是可行的。必须注意不要扩大解剖学或临床指南的范围。