Suppr超能文献

血管内修复破裂的腹主动脉瘤并不比开放修复有生存获益。

Endovascular repair of ruptured abdominal aortic aneurysm does not confer survival benefits over open repair.

机构信息

Division of Vascular Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pa 15213, USA.

出版信息

J Vasc Surg. 2012 Sep;56(3):614-9. doi: 10.1016/j.jvs.2012.01.081. Epub 2012 May 8.

Abstract

OBJECTIVE

Endovascular repair of ruptured abdominal aortic aneurysm (rAAA) is being increasingly performed despite lack of good evidence for its superiority. Other reported studies suffer from patient selection and publication bias with limited follow-up. This study is a single-center propensity score comparing early and midterm outcomes between open surgical repair (OSR) and endovascular repair of rAAA (REVAR).

METHODS

A retrospective review from January 2001 to November 2010 identified 312 patients who underwent rAAA repairs. Thirty-one patients with antecedent AAA repair and three with incomplete records were excluded, leaving 37 REVARs and 241 OSRs. Propensity score-based matching for sex, age, preoperative hemodynamic status, surgeon's annual AAA volume, and preoperative cardiopulmonary resuscitation was performed in a 1:3 ratio to compare outcomes. Thirty-seven REVARs were matched with 111 OSRs. Late survival was estimated by Kaplan-Meier methods.

RESULTS

Operative time and blood replacement were higher with OSR. Overall complication rates were similar (54% REVAR vs 66% OSR; P = .23), except for higher incidences of tracheostomies (21% vs 3%; P = .015), myocardial infarction (38% vs 18%; P = .036), and acute tubular necrosis (47% vs 21%; P = .009) with OSR. Operative mortality rates were similar (22% REVAR vs 32% OSR), with an odds ratio of 0.63 for REVAR (95% confidence interval = [0.24, 1.48]; P = .40). No differences in the incidences for secondary interventions for aneurysm- or graft-related complications were noted (22% REVAR vs 22% OSR; P = .99). Kaplan-Meier estimates of 1-, 2-, and 3-year survival rates were also similar (50%, 50%, 42% REVAR vs 54%, 52%, 47% OSR; P = .66).

CONCLUSIONS

REVAR for rAAA does not seem to conclusively confer either acute or late survival advantages. Routine use of REVAR should be deferred until prospective, randomized trial data become available.

摘要

目的

尽管缺乏血管内修复破裂腹主动脉瘤(rAAA)优越性的良好证据,但这种治疗方法的应用仍在不断增加。其他报道的研究存在患者选择和发表偏倚的问题,随访时间有限。本研究是单中心倾向评分比较开放手术修复(OSR)和 rAAA 血管内修复(REVAR)的早期和中期结果。

方法

回顾性分析 2001 年 1 月至 2010 年 11 月期间 312 例 rAAA 修复患者。排除 31 例既往 AAA 修复和 3 例记录不完整的患者,共纳入 37 例 REVAR 和 241 例 OSR。采用倾向评分匹配性别、年龄、术前血流动力学状态、术者每年 AAA 手术量和术前心肺复苏,以 1:3 的比例比较结果。37 例 REVAR 与 111 例 OSR 匹配。采用 Kaplan-Meier 方法估计晚期生存率。

结果

OSR 手术时间和血液置换量较高。整体并发症发生率相似(REVAR 为 54%,OSR 为 66%;P=.23),但 OSR 的气管切开术(21%比 3%;P=.015)、心肌梗死(38%比 18%;P=.036)和急性肾小管坏死(47%比 21%;P=.009)发生率较高。手术死亡率相似(REVAR 为 22%,OSR 为 32%),REVAR 的优势比为 0.63(95%置信区间[0.24,1.48];P=.40)。在与动脉瘤或移植物相关并发症的二次干预发生率方面,差异无统计学意义(REVAR 为 22%,OSR 为 22%;P=.99)。Kaplan-Meier 估计的 1、2、3 年生存率也相似(REVAR 为 50%、50%、42%,OSR 为 54%、52%、47%;P=.66)。

结论

rAAA 的 REVAR 似乎并不能明确带来急性或晚期生存优势。在获得前瞻性、随机试验数据之前,应推迟常规使用 REVAR。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验