Daher Wassim, Soldati-Favre Dominique
Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Geneva, Switzerland.
Curr Opin Microbiol. 2009 Aug;12(4):408-14. doi: 10.1016/j.mib.2009.06.008. Epub 2009 Jul 3.
The glideosome is a unique attribute of the Apicomplexa phylum. This myosin-based machine powers parasite motility, migration across biological barriers, host cell invasion and egress from infected cells. The timing, duration and orientation of gliding motility are tightly regulated to assure establishment of infection. Control of glideosome function occurs at several levels. The assembly of the molecular motor complex is governed by posttranslational modifications resulting from a calcium-dependent signalling cascade. The spatially controlled polymerization of actin filaments crucially impacts motility. The relocation of glycolytic enzymes in close proximity of the glideosome may enhance the local production of energy to sustain movement.
滑行体是顶复门的一个独特特征。这种基于肌球蛋白的机制驱动寄生虫的运动、穿越生物屏障、侵入宿主细胞以及从受感染细胞中逸出。滑行运动的时间、持续时间和方向受到严格调控，以确保感染的建立。滑行体功能的控制发生在多个层面。分子运动复合体的组装由钙依赖信号级联反应产生的翻译后修饰所调控。肌动蛋白丝的空间控制聚合对运动至关重要。糖酵解酶在滑行体附近的重新定位可能会增强局部能量产生以维持运动。
