口服激素避孕药会影响年轻女性尿液中糖胺聚糖的浓度和成分。
Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women.
作者信息
Zamboni Mary J G, Cabral Carlos A P, Sampaio Francisco J B, Cardoso Luiz E M
机构信息
Urogenital Research Unit-UERJ, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
Int Urogynecol J Pelvic Floor Dysfunct. 2009 Nov;20(11):1353-9. doi: 10.1007/s00192-009-0948-0. Epub 2009 Jul 4.
INTRODUCTION AND HYPOTHESIS
Urinary glycosaminoglycans (uGAG) have protective effects against urinary tract disorders. Here we investigated whether oral hormonal contraceptives (OC) affect uGAG excretion.
METHODS
Urine specimens were from young women regularly taking: ethinyl estradiol + drospirenone, n = 9; ethinyl estradiol + cyproterone acetate, n = 9; and ethinyl estradiol + gestodene, n = 7. Controls were from ten women not taking OC. Total uGAG was assayed as hexuronic acid/urinary creatinine. Sulfated uGAG species was determined by electrophoresis.
RESULTS
Unlike controls, total uGAG in the two halves of the menstrual cycle was similar in the OC groups. Whole cycle uGAG was higher in the OC groups (p < 0.01), especially for ethinyl estradiol + cyproterone acetate (p < 0.005). The three OC produced decreases of approximately 50% in heparan sulfate (p < 0.02) and dermatan sulfate (p < 0.02), and a approximately 100% increase in chondroitin sulfate (p < 0.004).
CONCLUSIONS
uGAG excretion is changed in women taking OC, and this might enhance the protective effects of these molecules against urinary tract disorders.
引言与假设
尿糖胺聚糖（uGAG）对尿路疾病具有保护作用。在此，我们研究了口服激素避孕药（OC）是否会影响uGAG的排泄。
方法
尿液标本来自规律服用以下药物的年轻女性：炔雌醇 + 屈螺酮，n = 9；炔雌醇 + 醋酸环丙孕酮，n = 9；以及炔雌醇 + 孕二烯酮，n = 7。对照组来自十名未服用OC的女性。总uGAG以己糖醛酸/尿肌酐进行测定。硫酸化uGAG种类通过电泳确定。
结果
与对照组不同，OC组月经周期两个半期的总uGAG相似。OC组全周期uGAG较高（p < 0.01），尤其是炔雌醇 + 醋酸环丙孕酮组（p < 0.005）。三种OC使硫酸乙酰肝素（p < 0.02）和硫酸皮肤素（p < 0.02）降低约50%，使硫酸软骨素增加约100%（p < 0.004）。
结论
服用OC的女性uGAG排泄发生改变，这可能增强这些分子对尿路疾病的保护作用。
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