Bishop Joseph R, Schuksz Manuela, Esko Jeffrey D
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Nature. 2007 Apr 26;446(7139):1030-7. doi: 10.1038/nature05817.
Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Studies of model organisms and human diseases have demonstrated their importance in development and normal physiology. A recurrent theme is the electrostatic interaction of the heparan sulphate chains with protein ligands, which affects metabolism, transport, information transfer, support and regulation in all organ systems. The importance of these interactions is exemplified by phenotypic studies of mice and humans bearing mutations in the core proteins or the biosynthetic enzymes responsible for assembling the heparan sulphate chains.
硫酸乙酰肝素蛋白聚糖存在于迄今为止所研究的所有动物细胞的质膜上，是细胞外基质的主要成分。对模式生物和人类疾病的研究表明了它们在发育和正常生理过程中的重要性。一个反复出现的主题是硫酸乙酰肝素链与蛋白质配体的静电相互作用，这影响了所有器官系统中的代谢、运输、信息传递、支持和调节。小鼠和人类中负责组装硫酸乙酰肝素链的核心蛋白或生物合成酶发生突变的表型研究证明了这些相互作用的重要性。
