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无溶剂条件下新型三足 Hantzsch 1,4-二氢吡啶的合成及其转化为相应的三足吡啶。

Synthesis of new tripodal Hantzsch 1,4-dihydropyridines under solvent-free condition and their conversion to the corresponding tripodal pyridines.

机构信息

Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran.

出版信息

Mol Divers. 2010 Nov;14(4):809-13. doi: 10.1007/s11030-009-9171-7. Epub 2009 Jul 4.

DOI:10.1007/s11030-009-9171-7
PMID:19578944
Abstract

A mixture of β-ketoester and tri-aldehydes in the presence of ammonium fluoride was converted to their corresponding tripodal 1,4-dihydropyridines under solvent-free condition with good yields. The obtained tripodal 1,4-dihydropyridines were also aromatized with oxone(®)/NaNO(2)/wet SiO(2) system under mild and heterogeneous conditions quantitatively.

摘要

在无溶剂条件下，β-酮酯和三醛混合物在氟化铵存在下转化为相应的三足 1,4-二氢吡啶，产率良好。所得三足 1,4-二氢吡啶也可在温和的多相条件下定量地用 Oxone(®)/NaNO(2)/湿 SiO(2)体系进行芳构化。

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Farmaco. 2003 Nov;58(11):1077-81. doi: 10.1016/S0014-827X(03)00159-9.
2
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Org Lett. 2002 Oct 31;4(22):3955-7. doi: 10.1021/ol0268135.
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Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells.
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Biochem Pharmacol. 2003 Feb 1;65(3):329-38. doi: 10.1016/s0006-2952(02)01488-0.