Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
Department of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ, 07102, USA.
Sci Rep. 2022 Aug 11;12(1):13687. doi: 10.1038/s41598-022-17378-7.
In this study, we reported the ammonium metavanadate (NHVO) as an efficient, cost-effective, and mild catalyst for the synthesis of substituted pyridines via a one-pot pseudo four-component reaction. Furthermore, we investigated Hantzsch 1,4-dihydropyridines (1,4-DHPs) synthesis and oxidation of 1,4-DHPs to their corresponding pyridines. The present approach offers a rapid methodology for accessing various pyridines with broad functional group tolerance and good yields using NHVO catalyst as a green catalyst.
在这项研究中,我们报告了偏钒酸铵(NHVO)作为一种高效、经济实惠且温和的催化剂,可通过一锅法伪四组分反应合成取代吡啶。此外,我们还研究了 Hantzsch 1,4-二氢吡啶(1,4-DHPs)的合成以及 1,4-DHPs 氧化为相应的吡啶。本方法提供了一种使用 NHVO 催化剂作为绿色催化剂,通过快速方法合成各种具有广泛官能团容忍度和良好收率的吡啶的方法。