Paniagua P, Pérez A
Servicio de Anestesia, Hospital de la Santa Creu i Sant Pau, UAB, Barcelona.
Rev Esp Anestesiol Reanim. 2009 May;56(5):299-311. doi: 10.1016/s0034-9356(09)70399-8.
Surgery produces a neuroendocrine stress response that affects resistance to insulin, reduces insulin secretion, and increases the release of glucose from the liver. This situation can trigger hyperglycemia in both diabetics and nondiabetics. Hyperglycemia has been linked to an increase in the morbidity and mortality among patients who undergo cardiac surgery, and the benefits of correcting hyperglycemia in this setting by means of intensive insulin therapy are well documented. This review discusses various aspects of hyperglycemia, particularly the evidence supporting stricter control of this condition in patients undergoing cardiac surgery. Furthermore, based on the available data and recommendations, and our clinical experience, we suggest therapeutic strategies to improve the control of hyperglycemia in these patients.
手术会引发神经内分泌应激反应,这种反应会影响胰岛素抵抗、减少胰岛素分泌,并增加肝脏葡萄糖的释放。这种情况可在糖尿病患者和非糖尿病患者中引发高血糖。高血糖与心脏手术患者的发病率和死亡率增加有关,通过强化胰岛素治疗纠正这种情况下的高血糖的益处已有充分记录。本综述讨论了高血糖的各个方面,特别是支持在心脏手术患者中更严格控制这种情况的证据。此外,根据现有数据和建议以及我们的临床经验,我们提出了改善这些患者高血糖控制的治疗策略。