Buchan I E, Bird H A
Clinical Pharmacology Unit (Rheumatism Research), University of Leeds, Royal Bath Hospital, Harrogate, United Kingdom.
Ann Rheum Dis. 1991 Oct;50(10):680-1. doi: 10.1136/ard.50.10.680.
The drug treatment of 100 consecutive new patients admitted to a regional rheumatology centre was reviewed. Potential drug interactions actions were sought according to appendix one of the British National Formulary (September 1989) and identified in 55 of 100 patients. The clinical and laboratory features of these patients were then reviewed, showing that only 11 displayed clinical manifestations of a drug interaction. Five patients had drug induced drowsiness, which was easily corrected, five a raised serum creatinine, which was less easily corrected, and one both. Although there is considerable potential for drug interaction in patients with severe arthritis, the proportion of patients who display clinical manifestations of this is small.
对一家地区性风湿病中心收治的100例连续新患者的药物治疗情况进行了回顾。根据《英国国家处方集》（1989年9月）附录一查找潜在的药物相互作用，并在100例患者中的55例中发现了这种相互作用。然后对这些患者的临床和实验室特征进行了回顾，结果显示只有11例出现了药物相互作用的临床表现。5例患者出现药物引起的嗜睡，很容易纠正；5例患者血清肌酐升高，较难纠正；1例患者两者都有。虽然重症关节炎患者存在相当大的药物相互作用可能性，但出现这种临床表现的患者比例较小。
