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老年人关节炎的药物治疗

Drug management of arthritis in the elderly.

作者信息

Fleming A

机构信息

Orpington Hospital, Bromley, Kent, UK.

出版信息

J R Soc Med. 1994;87 Suppl 23(Suppl 23):22-5.

Abstract

Rheumatic disorders are common in the ageing population requiring the use of DMARDs and immunosuppressive therapy as with younger patients. Indications for therapy are approximately the same in both groups, but toxic side-effects are probably more common in the elderly necessitating close supervision of indications and drug requirements. Local injection techniques The practice of local injection of corticosteroid in musculo-skeletal disorders is widespread. The literature on comparative efficacy between different preparations is scanty. These techniques can give significant relief in rheumatoid arthritis, osteoarthritis, sero negative arthropathies, crystal induced arthritis and many soft tissue lesions. Severe joint and soft tissue lesions are common in the elderly. In these patients even a small loss of physical function may have a markedly detrimental effect on independence. Such lesions should therefore be actively sought and vigorously treated. Often a simple, rapidly acting, local corticosteroid injection is preferable to a prolonged course of either NSAIDs or physiotherapy. In general, such injections should not be used if the diagnosis is uncertain, or there is any suspicion of infection, or if there has been a previous severe local reaction. Injections that are becoming too regular mean that the technique has not proved successful and other therapies should be sought. In performing the injections, antisepsis should be scrupulous and a 'no-touch' technique used. Accuracy of needle placement is necessary for good results. Injections should not be given against pressure as this generally means incorrect sitting. Some systemic absorption does occur.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

风湿性疾病在老年人群中很常见,与年轻患者一样需要使用改善病情抗风湿药(DMARDs)和免疫抑制疗法。两组的治疗指征大致相同,但老年患者的毒性副作用可能更常见,因此需要密切监测指征和药物需求。局部注射技术 在肌肉骨骼疾病中局部注射皮质类固醇的做法很普遍。关于不同制剂之间比较疗效的文献很少。这些技术可以显著缓解类风湿性关节炎、骨关节炎、血清阴性关节炎、晶体性关节炎和许多软组织病变。严重的关节和软组织病变在老年人中很常见。在这些患者中,即使身体功能有轻微丧失也可能对其独立性产生明显不利影响。因此,应积极寻找并大力治疗此类病变。通常,简单、起效快的局部皮质类固醇注射比长期使用非甾体抗炎药或物理治疗更可取。一般来说,如果诊断不确定、怀疑有感染或以前有过严重的局部反应,就不应使用此类注射。注射过于频繁意味着该技术未被证明成功,应寻求其他治疗方法。进行注射时,应严格进行消毒,并采用“无接触”技术。准确的进针位置对于取得良好效果很有必要。不应在有压力的情况下注射,因为这通常意味着位置不正确。确实会发生一些全身吸收。(摘要截取自250字)

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本文引用的文献

1
Local injection techniques.局部注射技术。
Med J Aust. 1981 May 16;1(10):512-4, 516. doi: 10.5694/j.1326-5377.1981.tb135775.x.
3
Side-effects of non-steroidal anti-inflammatory drugs.非甾体抗炎药的副作用。
Med J Aust. 1988 Mar 7;148(5):248-51. doi: 10.5694/j.1326-5377.1988.tb99435.x.
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Non-steroidal and analgesic therapy in the elderly.
Clin Rheum Dis. 1986 Apr;12(1):245-73.
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Drugs and the elderly.药物与老年人
Ann Rheum Dis. 1990 Dec;49(12):1021-2. doi: 10.1136/ard.49.12.1021.
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Drug interactions in arthritic patients.关节炎患者的药物相互作用
Ann Rheum Dis. 1991 Oct;50(10):680-1. doi: 10.1136/ard.50.10.680.
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Nonsteroidal anti-inflammatory drug gastropathy--is it preventable?非甾体抗炎药所致胃病——可预防吗?
Aust N Z J Med. 1992 Dec;22(6):685-91. doi: 10.1111/j.1445-5994.1992.tb04871.x.

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