5-羟色胺和组胺对树鼩（笔尾树鼩）离体回肠的作用。
The actions of 5-hydroxytryptamine and histamine on the isolated ileum of the tree shrew (Tupaia glis).
作者信息
Sakai K, Shiraki Y, Tatsumi T, Tsuji K
出版信息
Br J Pharmacol. 1979 Jul;66(3):405-8. doi: 10.1111/j.1476-5381.1979.tb10845.x.
Abstract
- Contractions to 5-hydroxytryptamine (5-HT) and histamine of longitudinal muscle from the isolated ileum of the tree shrew (Tupaia), guinea-pig and rat were investigated by constructing dose-response curves and studying the effects of various antagonists. 2 In the Tupaia and rat ileum the contraction to 5-HT was reduced by methysergide but not affected by tetrodotoxin (TTX), morphine, hexamethonium (C6) or atropine. The response of guinea-pig ileum to 5-HT was not significantly inhibited by methysergide or C6, but was blocked by TTX, morphine and atropine. 3 Histamine-induced contraction of Tupaia and guinea-pig ileum was antagonized by diphenhydramine but not by TTX, morphine, C6 or atropine. Histamine was almost without effect on the rat ileum.
摘要
- 通过构建剂量反应曲线并研究各种拮抗剂的作用，对树鼩（树鼩属）、豚鼠和大鼠离体回肠纵行肌对5-羟色胺（5-HT）和组胺的收缩反应进行了研究。2 在树鼩和大鼠回肠中，美西麦角可降低对5-HT的收缩反应，但不受河豚毒素（TTX）、吗啡、六甲铵（C6）或阿托品的影响。豚鼠回肠对5-HT的反应未被美西麦角或C6显著抑制，但被TTX、吗啡和阿托品阻断。3 苯海拉明可拮抗组胺引起的树鼩和豚鼠回肠收缩，但TTX、吗啡、C6或阿托品则不能。组胺对大鼠回肠几乎没有作用。
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Phyletic position of tree shrews.树鼩的系统发育位置。
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Drugs which antagonize 5-hydroxytryptamine.拮抗5-羟色胺的药物。
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A pharmacological analysis of the mode of action of serotonin (5-hydroxytryptamine) upon the guinea-pig ileum.血清素（5-羟色胺）对豚鼠回肠作用方式的药理学分析。
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