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1
Male infertility and varicocele: myths and reality.男性不育与精索静脉曲张:误区与真相。
Hippokratia. 2007 Jul;11(3):99-104.
2
Varicocelectomy does not impact pregnancy outcomes following intracytoplasmic sperm injection procedures.精索静脉曲张切除术对卵胞浆内单精子注射术后的妊娠结局没有影响。
J Androl. 2012 Mar-Apr;33(2):239-43. doi: 10.2164/jandrol.110.011932. Epub 2011 Apr 7.
3
Microsurgical varicocelectomy for infertile couples with advanced female age: natural history in the era of ART.针对高龄女性不孕夫妇的显微外科精索静脉曲张切除术:辅助生殖技术时代的自然病程
J Androl. 2004 Nov-Dec;25(6):939-43. doi: 10.1002/j.1939-4640.2004.tb03165.x.
4
Bilateral is superior to unilateral varicocelectomy in infertile males with left clinical and right subclinical varicocele: a prospective randomized controlled study.对于患有左侧临床型和右侧亚临床型精索静脉曲张的不育男性,双侧精索静脉曲张切除术优于单侧:一项前瞻性随机对照研究。
Int Urol Nephrol. 2018 Feb;50(2):205-210. doi: 10.1007/s11255-017-1749-x. Epub 2017 Dec 5.
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[Bilateral microsurgical varicocelectomy in infertile men].[不育男性的双侧显微外科精索静脉曲张切除术]
Urologiia. 2004 May-Jun(3):21-5.
6
The varicocele and male infertility.精索静脉曲张与男性不育症。
Urol Clin North Am. 1981 Feb;8(1):41-51.
7
Semen parameters and pregnancy rates after microsurgical varicocelectomy in primary versus secondary infertile men.原发性与继发性不育男性显微外科精索静脉曲张切除术后的精液参数及妊娠率
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Is assisted reproduction the optimal treatment for varicocele-associated male infertility? A cost-effectiveness analysis.辅助生殖是精索静脉曲张相关性男性不育的最佳治疗方法吗?一项成本效益分析。
Urology. 1997 Jan;49(1):83-90. doi: 10.1016/S0090-4295(96)00379-2.
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Clinical outcome of intracytoplasmic sperm injection in infertile men with treated and untreated clinical varicocele.治疗和未治疗的临床精索静脉曲张男性的胞浆内精子注射的临床结局。
J Urol. 2010 Oct;184(4):1442-6. doi: 10.1016/j.juro.2010.06.004. Epub 2010 Aug 19.
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Is varicocelectomy beneficial in men previously deemed subfertile but with normal semen parameters based on the new guidelines? A retrospective study.精索静脉结扎术对新指南中基于正常精液参数但被认为是以前的不育男性有益吗?一项回顾性研究。
Urology. 2015 Feb;85(2):357-62. doi: 10.1016/j.urology.2014.10.031. Epub 2014 Oct 30.

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1
Comparative Impact of Microsurgical Varicocelectomy Versus Observation on Infertility in Infertile Men With Subclinical Varicocele.显微外科精索静脉曲张切除术与观察等待对亚临床精索静脉曲张不育男性生育能力的比较影响
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Challenging cases of adherent periarterial vein during subinguinal Fisch technique and subinguinal micro-varicocelecotmy and sclerotherapy: a prospective comparative study.腹股沟下 Fisch 技术、腹股沟下显微精索静脉曲张切除术及硬化疗法中动脉周围粘连静脉的疑难病例:一项前瞻性对照研究。
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Varicocele repair for severe oligoasthenoteratozoospermia: Scoping review of published guidelines, and systematic review of the literature.重度少弱畸精子症的精索静脉曲张修复术:已发表指南的范围综述及文献系统评价
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Varicocele and Interventional Radiology: A Comprehensive Case Study on Diagnosis, Therapeutic Intervention, and Implications for Reproductive Health.精索静脉曲张与介入放射学:关于诊断、治疗干预及对生殖健康影响的综合案例研究
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2995-S2998. doi: 10.4103/jpbs.jpbs_156_24. Epub 2024 May 29.
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A comparison between the efficacy and complication of laparoscopic and microsurgical varicocelectomy: Systematic review and meta-analysis.腹腔镜与显微外科精索静脉曲张切除术的疗效与并发症比较:系统评价与荟萃分析
Urol Ann. 2024 Apr-Jun;16(2):113-119. doi: 10.4103/ua.ua_3_23. Epub 2024 Apr 18.
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Implications of Human Chorionic Gonadotropin (hCG) Therapy in a Varicocele Patient and Its Effect on In Vitro Fertilization (IVF) Outcome.人绒毛膜促性腺激素(hCG)疗法对精索静脉曲张患者的影响及其对体外受精(IVF)结局的作用
Cureus. 2024 Feb 25;16(2):e54893. doi: 10.7759/cureus.54893. eCollection 2024 Feb.
7
[Epidemio-clinical and seminal profile of the man consulting for the desire to procreate: current situation in Lubumbashi, in the Democratic Republic of Congo].[因生育意愿前来咨询的男性的流行病学临床及精液特征:刚果民主共和国卢本巴希的现状]
Pan Afr Med J. 2023 Aug 22;45:177. doi: 10.11604/pamj.2023.45.177.36977. eCollection 2023.
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Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data.精索静脉曲张修复术能否改善传统精液参数?一项前后数据的荟萃分析研究。
World J Mens Health. 2024 Jan;42(1):92-132. doi: 10.5534/wjmh.230034. Epub 2023 Jun 22.
9
Seminal Calbindin 2 in Infertile Men With Varicocele: A Prospective Comparative Study.精索静脉曲张不育症患者精囊钙结合蛋白 2:一项前瞻性对照研究。
Reprod Sci. 2023 Oct;30(10):3077-3083. doi: 10.1007/s43032-023-01237-5. Epub 2023 Apr 17.
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NGF and the Male Reproductive System: Potential Clinical Applications in Infertility.神经生长因子与男性生殖系统:在不孕不育中的潜在临床应用。
Int J Mol Sci. 2022 Oct 28;23(21):13127. doi: 10.3390/ijms232113127.

本文引用的文献

1
A consideration of sterility factors in the light of subsequent pregnancies. II. Sub fertility in the male. (Tr. Edinburgh Obst. Soc. Session 104).基于后续妊娠情况对不育因素的考量。二、男性生育力低下。(《爱丁堡产科学会会刊》第104期译文)
Edinb Med J. 1951;59(3):29-34.
2
The effects of sperm quality on embryo development after intracytoplasmic sperm injection.卵胞浆内单精子注射后精子质量对胚胎发育的影响。
J Assist Reprod Genet. 2006 Feb;23(2):69-74. doi: 10.1007/s10815-006-9022-8. Epub 2006 Mar 31.
3
Induction of spermatogenesis in azoospermic men after varicocelectomy repair: an update.
Fertil Steril. 2006 Mar;85(3):635-9. doi: 10.1016/j.fertnstert.2005.08.043.
4
Semen profile, testicular volume, and hormonal levels in infertile patients with varicoceles compared with fertile men with and without varicoceles.与有或无精索静脉曲张的 fertile 男性相比,精索静脉曲张不育患者的精液参数、睾丸体积和激素水平。 (注:fertile 在此语境下可能表述有误,推测原文想表达的是“有生育能力的”,可根据实际情况修正为“有生育能力的男性” 与“不育男性” 等更准确表述 )
Fertil Steril. 2005 Jan;83(1):74-7. doi: 10.1016/j.fertnstert.2004.06.047.
5
Report on varicocele and infertility.精索静脉曲张与不孕的报告。
Fertil Steril. 2004 Sep;82 Suppl 1:S142-5. doi: 10.1016/j.fertnstert.2004.05.057.
6
Role of varicocelectomy in men with nonobstructive azoospermia.精索静脉曲张切除术在非梗阻性无精子症男性中的作用。
Fertil Steril. 2004 Jun;81(6):1585-8. doi: 10.1016/j.fertnstert.2003.10.036.
7
The male factor in fertility and infertility. II. Spermatozoon counts in 1000 men of known fertility and in 1000 cases of infertile marriage.生育与不育中的男性因素。II. 1000名已知生育能力男性及1000例不育婚姻男性的精子计数
J Urol. 1951 Sep;66(3):436-49. doi: 10.1016/S0022-5347(17)74358-3.
8
Assessment of efficacy of varicocele repair for male subfertility: a systematic review.精索静脉曲张修复术治疗男性不育症的疗效评估:一项系统评价
Lancet. 2003 May 31;361(9372):1849-52. doi: 10.1016/S0140-6736(03)13503-9.
9
The cost-effectiveness of treatment for varicocele related infertility.
J Urol. 2002 Dec;168(6):2490-4. doi: 10.1016/S0022-5347(05)64175-4.
10
Does treatment of varicocele improve male fertility? results of the 'Deutsche Varikozelenstudie', a multicentre study of 14 collaborating centres.
Andrologia. 2002 Jun;34(3):164-71. doi: 10.1046/j.1439-0272.2002.00494.x.

男性不育与精索静脉曲张:误区与真相。

Male infertility and varicocele: myths and reality.

作者信息

Kantartzi P D, Goulis Ch D, Goulis G D, Papadimas I

机构信息

Unit of Reproductive Endocrinology, First Department of Obstetrics & Gynecology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.

出版信息

Hippokratia. 2007 Jul;11(3):99-104.

PMID:19582201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2658802/
Abstract

Varicocele is among the most common causes of male infertility. It is also one of the most controversial issues in the field of Andrology, especially regarding why, when and to whom varicocelectomy should be applied. Many experts believe that the surgical repair of varicocele should be applied only in a meticulously selected group of infertile men, although there are no generally accepted criteria. Up to now, the only confirmed prognostic factor for achievement of pregnancy after varicocelectomy is the age of the female partner. Given the wide application of intra-cytoplasmic sperm injection (ICSI) during the last few years, the modern research approaches should compare the benefits of varicocelectomy and ICSI, taking under consideration both the efficacy and the cost-effectiveness of the methods.

摘要

精索静脉曲张是男性不育最常见的病因之一。它也是男科学领域最具争议的问题之一,尤其是在精索静脉曲张切除术为何时、对何人应用方面。许多专家认为,精索静脉曲张的手术修复仅应应用于精心挑选的不育男性群体,尽管尚无普遍接受的标准。到目前为止,精索静脉曲张切除术后实现妊娠的唯一已证实的预后因素是女性伴侣的年龄。鉴于过去几年卵胞浆内单精子注射(ICSI)的广泛应用,现代研究方法应在考虑方法的有效性和成本效益的同时,比较精索静脉曲张切除术和ICSI的益处。