通过Pd(OAc)₂催化的区域选择性6-内型-双烯加成到碳-碳三键上高效合成膦酰化异苯并呋喃。
Efficient syntheses of phosphonylated isochromenes by regioselective 6-endo-dig addition to carbon-carbon triple bond catalyzed by Pd(OAc)2.
作者信息
Wang Fei, Miao Zhiwei, Chen Ruyu
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China.
出版信息
Org Biomol Chem. 2009 Jul 21;7(14):2848-50. doi: 10.1039/b908313h. Epub 2009 May 28.
DOI:10.1039/b908313h
PMID:19582292
Abstract
Palladium(II)-catalyzed cycloisomerization of [(2-alkynylphenyl)hydroxymethyl]phosphonates 6 provides an efficient route to phosphonylated isochromenes 7 in THF at room temperature and the reaction proceeded in a regioselective manner leading to the 6-endo-dig products 7 in moderate to excellent yields.
摘要
钯（II）催化的[(2-炔基苯基)羟甲基]膦酸酯6的环异构化反应在室温下于四氢呋喃中提供了一条合成膦酰化异苯并二氢吡喃7的有效途径，该反应以区域选择性方式进行，生成6-内型-双环化产物7，产率中等至优异。
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