通过钯催化的乙烯基醚区域选择性芳基化反应高效合成烷基芳基酮和缩酮。
Efficient synthesis of alkyl aryl ketones & ketals via palladium-catalyzed regioselective arylation of vinyl ethers.
机构信息
Department of Chemistry, Renmin University of China, Beijing, 100872, China.
出版信息
Org Biomol Chem. 2010 May 7;8(9):2012-5. doi: 10.1039/c001004a. Epub 2010 Mar 22.
DOI:10.1039/c001004a
PMID:20401375
Abstract
The combination of Pd(OAc)(2) with 1,3-bis(diphenylphosphino)propane (dppp) in ethylene glycol constitutes a high-performance catalytic system for highly regioselective arylation of a range of electron-rich vinyl ethers by aryl bromides to provide, upon hydrolysis, alkyl aryl ketones and cyclic ketals in good yields with up to 3.75 x 10(5) TON and 15625 h(-1) TOF.
摘要
Pd(OAc)(2)与 1,3-双(二苯基膦基)丙烷(dppp)在乙二醇中的组合构成了一种高性能催化体系，可通过芳基溴对一系列富电子乙烯基醚进行高区域选择性芳基化，得到烷基芳基酮和环状缩酮，水解后产率高达 3.75 x 10(5) TON 和 15625 h(-1) TOF。
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