心脏骤停与复苏后血浆中神经元特异性烯醇化酶浓度的变化。

Changes of neuron-specific enolase concentration in plasma after cardiac arrest and resuscitation.

作者信息

Dauberschmidt R, Zinsmeyer J, Mrochen H, Meyer M

机构信息

Research Department of Intensive Care Medicine, Friedrichshain Hospital, Berlin, Germany.

出版信息

Mol Chem Neuropathol. 1991 Jun;14(3):237-45. doi: 10.1007/BF03159939.

DOI:10.1007/BF03159939

PMID:1958265

Abstract

The concentration of neuron-specific enolase (NSE) was measured in plasma of 18 patients after cardiac arrest and resuscitation (14 nonsurvivors and 4 survivors). In all patients, the NSE concentration was significantly higher in comparison to reference values. The highest concentration was measured in nonsurvivors. Time-course investigation in the first 24 h after cardiac arrest was performed in five patients. Two nonsurvivors and one survivor of the five patients showed a significant rise, and a NSE peak concentration of 42.7 micrograms/L, 13.6 micrograms/L, and 10.5 micrograms/L, respectively, was found 10-19 h after cardiac arrest.

摘要

在18例心脏骤停并复苏患者（14例未存活者和4例存活者）的血浆中测量了神经元特异性烯醇化酶（NSE）的浓度。与参考值相比，所有患者的NSE浓度均显著更高。未存活者的浓度最高。对5例患者在心脏骤停后的最初24小时内进行了时间进程研究。这5例患者中的2例未存活者和1例存活者显示出显著升高，在心脏骤停后10 - 19小时分别发现NSE峰值浓度为42.7微克/升、13.6微克/升和10.5微克/升。