Zackrisson B U, Nyström U H, Ostbergh P
Department of Oncology, University of Umeå, Sweden.
Acta Oncol. 1991;30(6):747-51. doi: 10.3109/02841869109092451.
Several studies of biological response to ionizing radiation of high absorbed dose rates have been performed, often with conflicting results. The aim of this study was to establish whether a difference between irradiation at high dose rates and at more conventional dose rates could be verified. Pulsed 50 MeV electrons from a clinical accelerator were used both for the high dose rate experiments (mean dose rate: 3.8 x 10(2) Gy/s) and the reference experiments (mean dose rate: 9.6 x 10(-2) Gy/s). In this study V-79 cells were irradiated in vitro. The experiments were carried out under both oxic and anoxic conditions. No significant difference in relative biological effectiveness (RBE) or oxygen enhancement ratio (OER) was observed at the different dose rates investigated.
已经进行了几项关于高吸收剂量率电离辐射生物反应的研究，结果常常相互矛盾。本研究的目的是确定高剂量率照射与更传统剂量率照射之间是否存在差异。来自临床加速器的脉冲50 MeV电子用于高剂量率实验（平均剂量率：3.8 x 10(2) Gy/s）和参考实验（平均剂量率：9.6 x 10(-2) Gy/s）。在本研究中，V-79细胞在体外接受照射。实验在有氧和无氧条件下进行。在所研究的不同剂量率下，未观察到相对生物效应（RBE）或氧增强比（OER）有显著差异。
