硝苯地平对健康志愿者中用作钙动力学标志物的葡萄糖酸锶处置的影响。
The effect of nifedipine on the disposition of strontium gluconate used as a kinetic marker for calcium in healthy volunteers.
作者信息
Moraes M E, Aronson J K, Grahame-Smith D G
机构信息
MRC Unit, Radcliffe Infirmary, Oxford.
出版信息
Br J Clin Pharmacol. 1991 Oct;32(4):441-5. doi: 10.1111/j.1365-2125.1991.tb03928.x.
Abstract
- We have studied the disposition of stable strontium after the intravenous administration of strontium gluconate to eight healthy male volunteers both in control conditions and while they were taking the calcium antagonist nifedipine 10 mg three times daily. 2. Nifedipine, presumably by its action in blocking voltage-operated calcium channels, altered the in vivo disposition of strontium, causing large reductions in the half-life and the apparent volume of distribution of strontium. Total and renal clearances of strontium were unaltered by nifedipine. 3. These results support our previous suggestion that the delineation of strontium disposition can be used as a means of studying calcium disposition in vivo in man, and of studying the effects of drugs and diseases on that disposition.
摘要
- 我们研究了八名健康男性志愿者静脉注射葡萄糖酸锶后稳定锶的处置情况，分别在对照条件下以及他们每日三次服用10毫克钙拮抗剂硝苯地平的情况下进行了研究。2. 硝苯地平可能通过其阻断电压依赖性钙通道的作用，改变了锶在体内的处置，导致锶的半衰期和表观分布容积大幅降低。硝苯地平对锶的总清除率和肾清除率没有影响。3. 这些结果支持了我们之前的观点，即锶处置的描述可作为研究人体体内钙处置以及研究药物和疾病对该处置影响的一种手段。
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