维拉帕米治疗患者的钙吸收与排泄
Calcium absorption and excretion in patients treated with verapamil.
作者信息
Sjödén G, Rosenqvist M, Kriegholm E, Haglund K
机构信息
Department of Orthopaedic Surgery, Karolinska Institute, Huddinge University Hospital, Sweden.
出版信息
Br J Clin Pharmacol. 1987 Sep;24(3):367-71. doi: 10.1111/j.1365-2125.1987.tb03182.x.
Abstract
- The effect of verapamil on the intestinal absorption of calcium was studied using a single isotope technique. Serum calcium and urinary excretion of calcium in the urine were followed in nine patients during treatment with verapamil for 2 months. 2. A dose of 80-120 mg (three times daily) resulted in a significant reduction of systolic and diastolic blood pressure. 3. There was no change in the intestinal calcium absorption (alpha) expressed as the fraction of given activity absorbed per hour (alpha = 0.82 +/- 0.19 vs alpha = 0.83 +/- 0.25; +/- s.d., NS) or of the excretion of calcium in urine (Ca/creatinine ratio 0.35 +/- 0.20 vs 0.31 +/- 0.33; NS). 4. Serum calcium was not significantly different before and during treatment (2.43 mmol l-1 +/- 0.10 vs 2.47 mmol l-1 +/- 0.14; NS). 5. This study demonstrates that verapamil, at doses recommended for clinical use, does not seem to affect the intestinal absorption of calcium, the serum calcium concentration or the excretion of calcium in urine.
摘要
- 采用单同位素技术研究了维拉帕米对钙肠道吸收的影响。在9例患者接受维拉帕米治疗2个月期间，对血清钙和尿钙排泄情况进行了跟踪观察。2. 80 - 120毫克（每日三次）的剂量使收缩压和舒张压显著降低。3. 以每小时吸收的给定活性分数表示的肠道钙吸收（α）（α = 0.82 ± 0.19对比α = 0.83 ± 0.25；±标准差，无显著性差异）或尿钙排泄（钙/肌酐比值0.35 ± 0.20对比0.31 ± 0.33；无显著性差异）均无变化。4. 治疗前和治疗期间血清钙无显著差异（2.43毫摩尔/升± 0.10对比2.47毫摩尔/升± 0.14；无显著性差异）。5. 本研究表明，临床推荐剂量的维拉帕米似乎不影响钙的肠道吸收、血清钙浓度或尿钙排泄。
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