对华法林与西咪替丁在人体内的立体选择性相互作用的进一步深入了解。
Further insight into the stereoselective interaction between warfarin and cimetidine in man.
作者信息
Niopas I, Toon S, Rowland M
机构信息
Department of Pharmacy, Aristotle University of Thessaloniki, Greece.
出版信息
Br J Clin Pharmacol. 1991 Oct;32(4):508-11. doi: 10.1111/j.1365-2125.1991.tb03940.x.
Abstract
The urinary profile of R- and S-warfarin, following administration of a single (25 mg) oral dose of racemic warfarin, alone or on day 4 of a 9-day chronic administration of cimetidine (800 mg once daily), was investigated in eight healthy male volunteers. Based on estimated apparent formation clearance values, cimetidine inhibited significantly only the formation of R-6-hydroxywarfarin and R-7-hydroxywarfarin.
摘要
在8名健康男性志愿者中，研究了单剂量口服消旋华法林（25毫克）后，单独使用或在西咪替丁（每日一次，800毫克）9天慢性给药的第4天使用时，R-和S-华法林的尿液情况。根据估计的表观形成清除率值，西咪替丁仅显著抑制R-6-羟基华法林和R-7-羟基华法林的形成。
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1
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2
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3
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4
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5
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6
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