甲型血友病中T细胞对凝血因子VIII的致敏作用？

T cell sensitization to factor VIII in haemophilia A?

作者信息

Madhok R, Smith J, Jenkins A, Lowe G D

机构信息

University Department of Medicine, Royal Infirmary, Glasgow.

出版信息

Br J Haematol. 1991 Oct;79(2):235-8. doi: 10.1111/j.1365-2141.1991.tb04527.x.

DOI:10.1111/j.1365-2141.1991.tb04527.x

PMID:1958481

Abstract

Previous studies have indicated that factor VIII concentrates have a direct inhibitory effect on the proliferation of peripheral blood mononuclear cells (PBMC) obtained from normal volunteers. We have studied the effects of an intermediate and high purity factor VIII concentrate on haemophiliac PBMC. Intermediate purity factor VIII concentrate inhibited PBMC proliferation, the high purity factor VIII concentrate had no effect. The high purity factor VIII concentrate increased production of the lymphokine interleukin 2, suggesting the presence of a clone of T cells sensitized to factor VIII.

摘要

先前的研究表明，凝血因子VIII浓缩物对从正常志愿者获取的外周血单个核细胞（PBMC）的增殖具有直接抑制作用。我们研究了中纯度和高纯度凝血因子VIII浓缩物对血友病患者PBMC的影响。中纯度凝血因子VIII浓缩物抑制PBMC增殖，而高纯度凝血因子VIII浓缩物则无此作用。高纯度凝血因子VIII浓缩物增加了淋巴因子白细胞介素2的产生，提示存在对凝血因子VIII敏感的T细胞克隆。