Vujanovic Anka A, Zvolensky Michael J
Alpert Medical School of Brown University.
University of Vermont.
Exp Clin Psychopharmacol. 2009 Jun;17(3):181-190. doi: 10.1037/a0016266.
The present investigation examined the moderating role of anxiety sensitivity (AS) in regard to the relation between acute nicotine withdrawal and anxious and fearful responding to a 10% carbon dioxide-enriched air (CO2) procedure. Ninety daily smokers (35 women; M(age) = 28.87, SD = 12.12) were assigned randomly to one of two groups (12-hr nicotine deprivation or smoking "as usual") and subsequently underwent a 10% CO2 provocation challenge. Partially consistent with prediction, results indicated that the AS by nicotine withdrawal (group status) interaction was significantly predictive of peri-challenge anxiety ratings (anxiety during the challenge), but not skin conductance reactivity. Findings are discussed in the context of the role of AS in amplifying smoking-based fear responses to bodily sensations.
本研究考察了焦虑敏感性（AS）在急性尼古丁戒断与对10%二氧化碳富集空气（CO2）程序产生焦虑和恐惧反应之间关系中的调节作用。90名每日吸烟者（35名女性；年龄均值M = 28.87，标准差SD = 12.12）被随机分配到两组之一（12小时尼古丁剥夺组或照常吸烟组），随后接受10% CO2激发挑战。结果部分符合预测，表明AS与尼古丁戒断（分组状态）的交互作用能显著预测挑战期间的焦虑评分（挑战过程中的焦虑），但不能预测皮肤电反应性。研究结果在AS在放大基于吸烟的对身体感觉的恐惧反应中的作用背景下进行了讨论。
