Division of Infectious Disease, University of Louisville School of Medicine, Louisville, KY, USA.
Int J Infect Dis. 2010 Jan;14(1):e22-7. doi: 10.1016/j.ijid.2009.03.001. Epub 2009 Jul 7.
There are limited and conflicting data on clinical outcomes of community-acquired pneumonia (CAP) among HIV-infected patients.
Secondary analyses of clinical outcomes of CAP were performed for 118 patients with HIV infection and 2790 patients without HIV infection enrolled in the Community-Acquired Pneumonia Organization (CAPO) international study. After adjustment for significant confounders, the effect of HIV infection on length of stay (LOS) and time to clinical stability (TCS) were examined by survival analyses and overall mortality and CAP-related mortality by logistic regression methods.
After adjusting for significant confounders, hospitalized HIV-infected patients with CAP did not have longer times to reach clinical stability (HR 1.126; 95% CI 0.917-1.391; p=0.251) or longer stays in the hospital (HR 1.191, 95% CI 0.979-1.449; p=0.080). In addition, HIV infection did not significantly influence overall mortality rates (OR 1.205, 95% CI 0.686-2.116; p=0.517) or CAP-related mortality rates (OR 1.338; 95% CI 0.623-3.725; p=0.355).
The presence of HIV infection did not influence the clinical outcomes of CAP among patients assessed at CAPO centers. It is not intended that our results be extrapolated to populations receiving limited healthcare for advanced HIV disease, malnourishment and parasitic diseases.
有关艾滋病毒感染者社区获得性肺炎（CAP）的临床结局数据有限且相互矛盾。
对 118 例 HIV 感染患者和 2790 例无 HIV 感染患者的 CAP 临床结局进行二次分析，这些患者均参与了社区获得性肺炎组织（CAPO）国际研究。在调整了显著混杂因素后，通过生存分析和总体死亡率及 CAP 相关死亡率的 logistic 回归方法，研究了 HIV 感染对住院时间（LOS）和临床稳定时间（TCS）的影响。
在调整了显著混杂因素后，患有 CAP 的 HIV 感染住院患者并未出现达到临床稳定的时间延长（HR 1.126；95%CI 0.917-1.391；p=0.251）或住院时间延长（HR 1.191，95%CI 0.979-1.449；p=0.080）。此外，HIV 感染并未显著影响总体死亡率（OR 1.205，95%CI 0.686-2.116；p=0.517）或 CAP 相关死亡率（OR 1.338；95%CI 0.623-3.725；p=0.355）。
在 CAPO 中心评估的患者中，HIV 感染的存在并未影响 CAP 的临床结局。我们的研究结果不适用于接受有限的艾滋病晚期医疗保健、营养不良和寄生虫病治疗的人群。
