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HIV阳性患者的社区获得性肺炎:病因、流行病学及管理的最新进展

Community-Acquired Pneumonia in HIV-Positive Patients: an Update on Etiologies, Epidemiology and Management.

作者信息

Almeida André, Boattini Matteo

机构信息

Department of Internal Medicine 4, Hospital de Santa Marta, Central Lisbon Hospital Centre, Rua de Santa Marta, 1169-124, Lisbon, Portugal.

NOVA Medical School, Universidade Nova de Lisboa, Campo dos Mártires da Pátria 130, 1169-056, Lisbon, Portugal.

出版信息

Curr Infect Dis Rep. 2017 Jan;19(1):2. doi: 10.1007/s11908-017-0559-8.

Abstract

PURPOSE OF REVIEW

Community-acquired pneumonia (CAP) is the cause of a considerable burden of morbidity and mortality among HIV-infected patients. The purpose of this study was to review recent literature for epidemiological trends and management of CAP in HIV patients.

RECENT FINDINGS

While the specific infectious etiologies are very diverse, bacterial infection and tuberculosis are the main causes of CAP in this population. Bacterial CAP mostly affects high-income countries, while tuberculosis is mostly in low-/middle-income countries. Early antiretroviral therapy is of benefit for all patients regardless of etiology and immune status. Specific etiologies require individualized approaches, both therapeutically and prophylatically. Antiretroviral therapy is recommended for all patients.

摘要

综述目的

社区获得性肺炎(CAP)是HIV感染患者发病和死亡的重要原因。本研究旨在回顾近期有关HIV患者CAP流行病学趋势及管理的文献。

最新发现

虽然具体的感染病因非常多样,但细菌感染和结核病是该人群CAP的主要病因。细菌性CAP主要影响高收入国家,而结核病主要发生在低收入/中等收入国家。早期抗逆转录病毒治疗对所有患者都有益,无论病因和免疫状态如何。特定病因需要在治疗和预防方面采取个体化方法。建议对所有患者进行抗逆转录病毒治疗。

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