Department of Psychiatry and Human Behavior, University of California, Irvine, Orange, CA 92677, USA.
J Perinatol. 2009 Nov;29(11):731-7. doi: 10.1038/jp.2009.85. Epub 2009 Jul 9.
To determine whether prenatal treatment with a single course of glucocorticoids (GCs) affects size at birth among full-term infants independent of fetal size before GC administration or exposure to preterm labor (PTL).
In all, 105 full-term infants were recruited into three study groups (30 GC treated; 60 controls matched for gestational age (GA) at birth and sex; and 15 PTL controls without GC exposure). Size of the infants was estimated before treatment using two-dimensional (2D) ultrasound and by direct measurement at birth.
Length, weight and head circumference at birth were smaller among GC-treated infants compared with matched controls (P's<0.01), although fetal size did not differ before treatment (P's>0.2). Exposure to PTL did not account for this effect.
Prenatal treatment with a single course of GCs was associated with a reduction in size at birth among infants born at term gestation. This effect cannot be explained by differences in fetal size before treatment or exposure to PTL.
确定产前单次使用糖皮质激素（GCs）治疗是否会影响足月婴儿的出生体重，而不考虑 GC 给药前胎儿大小或早产（PTL）暴露情况。
共招募了 105 名足月婴儿进入三个研究组（30 名 GC 治疗组；60 名出生时 GA 和性别匹配的对照组；15 名无 GC 暴露的 PTL 对照组）。在治疗前使用二维（2D）超声和出生时直接测量来估计婴儿的大小。
与匹配对照组相比，GC 治疗组婴儿出生时的身长、体重和头围较小（P<0.01），尽管治疗前胎儿大小无差异（P>0.2）。PTL 暴露并不能解释这种影响。
产前单次使用 GCs 治疗与足月出生婴儿的出生体重下降有关。这种影响不能用治疗前胎儿大小或 PTL 暴露的差异来解释。
