Carillo Sara, Silipo Alba, Perino Vincenzo, Lanzetta Rosa, Parrilli Michelangelo, Molinaro Antonio
Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Via Cintia, 4 I-80126 Napoli, Italy.
Carbohydr Res. 2009 Sep 8;344(13):1697-700. doi: 10.1016/j.carres.2009.05.013. Epub 2009 May 18.
The pathogenic mechanisms of Gram-negative infection in cystic fibrosis are only just beginning to be explored at molecular level. Several virulence factors have been defined, one of the most important is the lipopolysaccharide molecule. In order to fully understand the mechanisms of bacterial infection and host recognition a full structure/activity study of lipopolysaccharide is needed. In the present paper, we define the complete structure of the O-specific polysaccharide from the lipopolysaccharide from Burkholderia anthina, an uncommon pathogen of cystic fibrosis patients.
囊性纤维化中革兰氏阴性菌感染的致病机制在分子水平上才刚刚开始被探索。已经确定了几种毒力因子，其中最重要的一种是脂多糖分子。为了全面了解细菌感染和宿主识别的机制，需要对脂多糖进行完整的结构/活性研究。在本文中，我们确定了来自洋葱伯克霍尔德菌脂多糖的O-特异性多糖的完整结构，洋葱伯克霍尔德菌是囊性纤维化患者的一种不常见病原体。
