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小儿喉软化症患者经口二氧化碳激光显微手术后的多导睡眠图结果

Polysomnography outcomes following transoral CO2 laser microsurgery in pediatric patients with laryngomalacia.

作者信息

Sesterhenn Andreas M, Zimmermann Annette P, Bernhard Michael, Kussin Andrea, Timmesfeld Nina, Stiller Susanne, Wiegand Susanne, Maier Rolf F, Werner Jochen A

机构信息

Department of Otolaryngology, Head & Neck Surgery, University Hospital of Giessen and Marburg, Campus Marburg, Deutschhausstrasse 3, D-35037 Marburg, Germany.

出版信息

Int J Pediatr Otorhinolaryngol. 2009 Oct;73(10):1339-43. doi: 10.1016/j.ijporl.2009.06.002. Epub 2009 Jul 8.

Abstract

OBJECTIVE

Laryngomalacia is the most common cause of stridor in newborns and infants. The aim of the contribution was to present objectified data of the outcome of transoral CO(2) laser microsurgery in patients with laryngomalacia utilizing polysomnography (PSG).

PATIENTS AND METHODS

This retrospective study comprised 21 patients who were diagnosed to suffer from laryngomalacia. Diagnosis was confirmed by pharyngo-laryngoscopy under spontaneous breathing. If there was evidence for laryngomalacia a transoral CO(2) lasersurgical intervention and/or epiglottopexy was performed in the same session. 8 patients, on whom the following should be focused, received pre- and postoperative PSG which was performed for efficiency control of the applied treatment.

RESULTS

All 21 patients underwent invasive treatment for laryngomalacia (lasersurgical division of the aryepiglottic folds: n=13; epiglottopexy: n=5; combined procedure: n=3). All patients were successfully extubated after surgery. In 20/21 cases breathing improved clearly after one single intervention. Stridor disappeared completely in the further course of the disease. In the 8 patients who received pre- and postinterventional PSG, lasersurgical interventions were performed. Statistical analysis of pre- and postoperative PSG revealed that MOAI/h (mixed obstructive apnea index/hour) improved significantly (p=0.016, Wilcoxon-Signed-Rank Test). Also desaturation/hour improved in the postoperative course (p=0.11).

CONCLUSION

The presented concept describes an effective and reliable approach for diagnostics and treatment for laryngomalacia. To objectify the success of supraglottoplaty in patients suffering from severe laryngomalacia a pre- and postoperative PSG seems to be useful and advisable. The present results of PSG demonstrate that children with laryngomalacia to benefit from lasersurgical division of the aryepiglottic folds and/or epiglottopexy. This fact is supported by the postoperative improved clinical aspect.

摘要

目的

喉软化症是新生儿和婴儿喘鸣最常见的原因。本研究旨在通过多导睡眠图(PSG)呈现喉软化症患者经口二氧化碳激光显微手术结果的客观数据。

患者与方法

这项回顾性研究纳入了21例被诊断为喉软化症的患者。通过自主呼吸下的咽喉镜检查确诊。若有喉软化症的证据,则在同一次手术中进行经口二氧化碳激光手术干预和/或会厌固定术。8例患者接受了术前和术后PSG检查,以评估所应用治疗的效果,以下将重点关注这8例患者。

结果

所有21例患者均接受了喉软化症的侵入性治疗(杓会厌襞激光手术切开:n = 13;会厌固定术:n = 5;联合手术:n = 3)。所有患者术后均成功拔管。20/21例患者在单次干预后呼吸明显改善。喘鸣在疾病的后续过程中完全消失。在接受术前和术后PSG检查的8例患者中,进行了激光手术干预。术前和术后PSG的统计分析显示,每小时混合性阻塞性呼吸暂停指数(MOAI/h)显著改善(p = 0.016,Wilcoxon符号秩检验)。术后每小时的血氧饱和度下降情况也有所改善(p = 0.11)。

结论

本研究提出的概念描述了一种有效且可靠的喉软化症诊断和治疗方法。为客观评估重度喉软化症患者声门上成形术的成功与否,术前和术后PSG似乎是有用且可取的。PSG的当前结果表明,喉软化症患儿可从杓会厌襞激光手术切开和/或会厌固定术中获益。这一事实得到了术后临床状况改善的支持。

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