超声辅助一锅法三组分合成1H-吡唑并[1,2-b]酞嗪-5,10-二酮
Ultrasound-assisted one-pot, three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones.
作者信息
Nabid Mohammad Reza, Rezaei Seyed Jamal Tabatabaei, Ghahremanzadeh Ramin, Bazgir Ayoob
机构信息
Department of Chemistry, Shahid Beheshti University, G.C., P.O. Box 19396-4716, Tehran, Iran.
出版信息
Ultrason Sonochem. 2010 Jan;17(1):159-61. doi: 10.1016/j.ultsonch.2009.06.012. Epub 2009 Jun 18.
Triethylamine was found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in ethanol under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of ethanol as a solvent that is considered to be relatively environmentally benign.
已发现三乙胺是通过邻苯二甲酰肼、芳香醛与丙二腈或氰基乙酸乙酯在乙醇中于超声辐射下一锅反应合成1H-吡唑并[1,2-b]酞嗪-5,10-二酮的有效催化剂。该方法的优点包括使用廉价且易于获得的催化剂、后处理简便、产率提高，以及使用乙醇作为溶剂，乙醇被认为相对环保。
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