Department of Phytochemistry, Shahid Beheshti University, Tehran, Iran.
Mol Divers. 2012 May;16(2):231-40. doi: 10.1007/s11030-011-9348-8. Epub 2011 Dec 11.
[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)(2)/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.
[(1,2,3-三唑-4-基)甲氧基-苯基]-2H-吲唑并[2,1-b]苯并二嗪-1,3-二酮衍生物通过邻苯二甲酰肼、芳香炔氧基醛、活性亚甲基化合物(二甲基酮和 1,3-环己二酮)和叠氮化物的一锅四组分缩合反应,在 Cu(OAc)(2)/抗坏血酸钠和对甲苯磺酸作为催化剂的条件下高效合成,产率良好至优秀。