• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

结合点击多组分反应：一锅法合成三唑基甲氧基-苯基吲唑并[2,1-b]酞嗪-1,3-二酮衍生物。

Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives.

机构信息

Department of Phytochemistry, Shahid Beheshti University, Tehran, Iran.

出版信息

Mol Divers. 2012 May;16(2):231-40. doi: 10.1007/s11030-011-9348-8. Epub 2011 Dec 11.

DOI:10.1007/s11030-011-9348-8
PMID:22161122
Abstract

[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)(2)/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.

摘要

[(1,2,3-三唑-4-基)甲氧基-苯基]-2H-吲唑并[2,1-b]苯并二嗪-1,3-二酮衍生物通过邻苯二甲酰肼、芳香炔氧基醛、活性亚甲基化合物（二甲基酮和 1,3-环己二酮）和叠氮化物的一锅四组分缩合反应，在 Cu(OAc)(2)/抗坏血酸钠和对甲苯磺酸作为催化剂的条件下高效合成，产率良好至优秀。

相似文献

1
Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives.结合点击多组分反应：一锅法合成三唑基甲氧基-苯基吲唑并[2,1-b]酞嗪-1,3-二酮衍生物。
Mol Divers. 2012 May;16(2):231-40. doi: 10.1007/s11030-011-9348-8. Epub 2011 Dec 11.
2
Synthesis of diheterocyclic compounds based on triazolyl methoxy phenylquinazolines via a one-pot four-component-click reaction.
J Comb Chem. 2010 Sep 13;12(5):638-42. doi: 10.1021/cc100043z.
3
SYNTHESIS AND EVALUATION OF NEW PHTHALAZINE SUBSTITUTED β-LACTAM DERIVATIVES AS CARBONIC ANHYDRASE INHIBITORS.新型酞嗪取代β-内酰胺衍生物作为碳酸酐酶抑制剂的合成与评价
Bioorg Khim. 2015 Jul-Aug;41(4):468-74. doi: 10.7868/s0132342315040119.
4
Ultrasound-promoted one-pot, three-component synthesis of spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] derivatives.超声促进的一锅法、三组分合成螺[吲哚啉-3,1'-吡唑并[1,2-b]酞嗪]衍生物。
Molecules. 2012 Jul 23;17(7):8674-86. doi: 10.3390/molecules17078674.
5
Ultrasound-promoted catalyst-free one-pot four component synthesis of 2H-indazolo[2,1-b]phthalazine-triones in neutral ionic liquid 1-butyl-3-methylimidazolium bromide.超声促进无催化剂一锅四组分合成 2H-吲哚并[2,1-b]酞嗪-1,3-二酮在中性离子液体 1-丁基-3-甲基咪唑溴化物中。
Ultrason Sonochem. 2012 Mar;19(2):307-13. doi: 10.1016/j.ultsonch.2011.07.011. Epub 2011 Jul 30.
6
A new inorganic-organic hybrid material Al-SBA-15-TPI/H6P2W18O62 catalyzed one-pot, three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones.一种新型无机-有机杂化材料Al-SBA-15-TPI/H6P2W18O62催化一锅法三组分合成2H-吲唑并[2,1-b]酞嗪三酮。
Dalton Trans. 2015 Mar 28;44(12):5888-97. doi: 10.1039/c4dt03504f.
7
Green Synthesis of Fused Chromeno-pyrazolo-phthalazine Derivatives with Silicasupported Bismuth Nitrate under Solvent-free Conditions.无溶剂条件下硅胶负载硝酸铋催化合成稠合色烯并吡唑并酞嗪衍生物的绿色合成法
Curr Org Synth. 2021;18(8):854-861. doi: 10.2174/1570179417666201208112520.
8
Superparamagnetic Poly(aniline-co-m-phenylenediamine)@FeO Nanocomposite as an Efficient Heterogeneous Catalyst for the Synthesis of 1-pyrazolo[1,2-]pyridazine-5,8-diones & 1-pyrazolo[1,2-]phthalazine-5, 10-diones Derivatives.超顺磁性聚（苯胺 - 间苯二胺）@FeO纳米复合材料作为合成1 - 吡唑并[1,2 - ]哒嗪 - 5,8 - 二酮和1 - 吡唑并[1,2 - ]酞嗪 - 5,10 - 二酮衍生物的高效多相催化剂
Curr Org Synth. 2022 Mar 3;19(2):246-266. doi: 10.2174/1570179418666211104143736.
9
Introducing new and effective catalysts for the synthesis of pyridazino[1,2-]indazole, indazolo[2,1-]phthalazine and pyrazolo[1,2-]phthalazine derivatives.介绍用于合成哒嗪并[1,2 -]吲唑、吲唑并[2,1 -]酞嗪和吡唑并[1,2 -]酞嗪衍生物的新型高效催化剂。
MethodsX. 2020 Feb 20;7:100823. doi: 10.1016/j.mex.2020.100823. eCollection 2020.
10
Ag NPs on chitosan-alginate coated magnetite for synthesis of indazolo[2,1-b]phthalazines and human lung protective effects against α-Guttiferin.壳聚糖-海藻酸钠包覆的磁性四氧化三铁负载银纳米粒子用于吲唑并[2,1-b]酞嗪的合成及抗α-倒捻子素的人肺保护作用
Int J Biol Macromol. 2020 Dec 1;164:2974-2986. doi: 10.1016/j.ijbiomac.2020.08.183. Epub 2020 Aug 25.

引用本文的文献

1
Novel L-tryptophan-functionalized zirconium dioxide nanoparticles catalysed one-pot and solvent-free synthesis of 2 H-indazolo [2, 1-b] phthalazine-triones.新型L-色氨酸功能化二氧化锆纳米颗粒催化一锅法无溶剂合成2H-吲唑并[2,1-b]酞嗪三酮。
Sci Rep. 2025 Jul 13;15(1):25323. doi: 10.1038/s41598-025-11227-z.

本文引用的文献

1
In situ click chemistry: a powerful means for lead discovery.原位点击化学：一种发现先导化合物的有力手段。
Expert Opin Drug Discov. 2006 Nov;1(6):525-38. doi: 10.1517/17460441.1.6.525.
2
Synthesis of diheterocyclic compounds based on triazolyl methoxy phenylquinazolines via a one-pot four-component-click reaction.
J Comb Chem. 2010 Sep 13;12(5):638-42. doi: 10.1021/cc100043z.
3
Ultrasound-assisted one-pot, three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones.超声辅助一锅法三组分合成1H-吡唑并[1,2-b]酞嗪-5,10-二酮
Ultrason Sonochem. 2010 Jan;17(1):159-61. doi: 10.1016/j.ultsonch.2009.06.012. Epub 2009 Jun 18.
4
The growing applications of click chemistry.点击化学日益增长的应用。
Chem Soc Rev. 2007 Aug;36(8):1249-62. doi: 10.1039/b613014n. Epub 2007 May 3.
5
Asymmetric multicomponent reactions (AMCRs): the new frontier.不对称多组分反应（AMCRs）：新前沿
Angew Chem Int Ed Engl. 2005 Mar 4;44(11):1602-34. doi: 10.1002/anie.200460548.
6
Combining Biginelli multicomponent and click chemistry: generation of 6-(1,2,3-triazol-1-yl)-dihydropyrimidone libraries.
J Comb Chem. 2004 Nov-Dec;6(6):884-92. doi: 10.1021/cc0498938.
7
Towards organo-click chemistry: development of organocatalytic multicomponent reactions through combinations of aldol, Wittig, Knoevenagel, Michael, Diels-Alder and Huisgen cycloaddition reactions.迈向有机点击化学：通过羟醛缩合、维蒂希反应、克诺文纳盖尔反应、迈克尔反应、狄尔斯-阿尔德反应和惠斯根环加成反应的组合开发有机催化多组分反应。
Chemistry. 2004 Oct 25;10(21):5323-31. doi: 10.1002/chem.200400597.
8
"Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.“多组分反应：药物发现中的新兴化学” 从昔罗卡因到克立芝
Curr Med Chem. 2003 Jan;10(1):51-80. doi: 10.2174/0929867033368600.
9
Click Chemistry: Diverse Chemical Function from a Few Good Reactions.点击化学：少数有效反应带来的多样化学功能
Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2004-2021. doi: 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5.
10
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.新型强效6,7-亚甲基二氧基酞嗪-1(2H)-酮的合成与抗惊厥活性
J Med Chem. 2000 Jul 27;43(15):2851-9. doi: 10.1021/jm001002x.