School of Medicine, National University of Athens, Athens, Greece.
Breast Cancer Res Treat. 2010 Feb;120(1):211-6. doi: 10.1007/s10549-009-0467-1. Epub 2009 Jul 10.
MDM2 SNP309 is a single nucleotide T > G polymorphism present in intron 1 of the MDM2 gene. A variety of case-control studies have been published evaluating the association between MDM2 SNP309 and breast cancer risk. However, the published studies, as well as the subsequent meta-analyses, have yielded contradictory results. This meta-analysis aims to examine whether MDM SNP309 polymorphism may exert a differential effect on breast cancer risk along with race. Eligible articles were identified by a search of MEDLINE, Cochrane and EMBASE bibliographical databases for the period July 1993 to June 2009; 16 case-control studies were eligible (12,986 breast cancer cases, 12,993 controls). Subanalyses in case-control studies conducted on Chinese (3 studies, 892 cases, 1,435 controls) and non-Chinese populations (13 studies, 12,094 cases, 11,558 controls) were performed. All pooled odds ratios (ORs) were derived from fixed-effects models given that the between-study heterogeneity was not statistically significant. Subanalysis on Chinese subjects demonstrated that GT and GG genotype were associated with increased breast cancer risk (pooled OR = 1.272, 95% CI 1.025-1.578 and pooled OR = 1.323, 95% CI 1.034-1.694, respectively); as a result the overall effect of the G allele was statistically significant (pooled OR = 1.287, 95% CI 1.048-1.579). On the contrary, no significant associations between MDM2 SNP309 status and breast cancer risk were demonstrated in non-Chinese populations. In conclusion, the association between MDM2 SNP309 and breast cancer is modified by race. MDM2 SNP309 represents a risk factor for breast cancer in Chinese women but not in non-Chinese women. This phenomenon is analogous to that described in the context of lung cancer.
MDM2 SNP309 是位于 MDM2 基因内含子 1 中的单核苷酸 T > G 多态性。已经发表了许多病例对照研究来评估 MDM2 SNP309 与乳腺癌风险之间的关联。然而，已发表的研究以及随后的荟萃分析得出了相互矛盾的结果。本荟萃分析旨在研究 MDM SNP309 多态性是否可能因种族不同而对乳腺癌风险产生不同的影响。通过对 MEDLINE、Cochrane 和 EMBASE 文献数据库进行检索，查找 1993 年 7 月至 2009 年 6 月期间的文献，确定了符合条件的文章；共纳入 16 项病例对照研究（12986 例乳腺癌病例，12993 例对照）。对在中国人群（3 项研究，892 例病例，1435 例对照）和非中国人群（13 项研究，12094 例病例，11558 例对照）进行病例对照研究的亚组分析。由于研究间异质性无统计学意义，所有汇总的比值比（ORs）均来自固定效应模型。在中国人群的亚组分析中，GT 和 GG 基因型与乳腺癌风险增加相关（汇总 OR = 1.272，95%CI 1.025-1.578 和汇总 OR = 1.323，95%CI 1.034-1.694）；因此，G 等位基因的总体效应具有统计学意义（汇总 OR = 1.287，95%CI 1.048-1.579）。相反，在非中国人群中，未发现 MDM2 SNP309 状态与乳腺癌风险之间存在显著关联。总之，MDM2 SNP309 与乳腺癌的关联受种族影响。MDM2 SNP309 代表中国女性乳腺癌的危险因素，但非中国女性则不是。这种现象类似于肺癌背景下所描述的现象。
