Bai Jianling, Dai Juncheng, Yu Hao, Shen Hongbing, Chen Feng
Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China.
J Toxicol Environ Health A. 2009;72(11-12):677-82. doi: 10.1080/15287390902840930.
MDM2 SNP309 polymorphism was found to contribute to genetic susceptibility to lung cancer in humans. However, association studies on these polymorphisms in lung cancer cases have shown conflicting results. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the strength of association between MDM2 SNP309 polymorphism and risk of lung cancer development. The logistic regression indicated that the genetic model was most likely to be recessive. Using a recessive model, the pooled OR estimating the genotype GG against the T-allele carriers (GT + TT) were calculated. Eight studies, including 6063 cases and 6678 controls, were involved in this meta-analysis. Overall meta-analysis indicated that MDM2 SNP309 GG genotypes have an approximate 16% increased risk for lung cancer development with a statistical significance (OR = 1.16; 95% CI: 1.01-1.34). In the subgroup analyses based on ethnicities, no significant elevated risk was associated with MDM2 SNP309 genotypes found in Asian and Europeans. No significant increased risk was associated with MDM2 SNP309 genotypes found in ever smokers. MDM2 SNP309 GG genotype had an approximate 36% enhanced risk of lung cancer development with statistical significance in never smokers (OR = 1.36; 95% CI: 1.10-1.68). Although some bias cannot be excluded, this meta-analysis supports the view that MDM2 SNP309 gene is a low-penetrance susceptible gene in the development of lung cancer, and the relationship of MDM2 SNP309 and lung cancer is stronger for never smokers.
已发现MDM2 SNP309多态性与人类肺癌的遗传易感性有关。然而，针对肺癌病例中这些多态性的关联研究结果相互矛盾。为了更精确地估计两者之间的关系，进行了一项荟萃分析。采用比值比（OR）及95%置信区间（CI）来评估MDM2 SNP309多态性与肺癌发生风险之间的关联强度。逻辑回归表明遗传模型最可能为隐性模型。采用隐性模型，计算了估计基因型GG相对于T等位基因携带者（GT + TT）的合并OR。八项研究纳入了本荟萃分析，共6063例病例和6678例对照。总体荟萃分析表明，MDM2 SNP309 GG基因型患肺癌的风险增加约16%，具有统计学意义（OR = 1.16；95% CI：1.01 - 1.34）。在基于种族的亚组分析中，未发现亚洲人和欧洲人中MDM2 SNP309基因型与显著升高的风险相关。在曾经吸烟者中，未发现MDM2 SNP309基因型与显著增加的风险相关。在从不吸烟者中，MDM2 SNP309 GG基因型患肺癌的风险增加约36%，具有统计学意义（OR = 1.36；95% CI：1.10 - 1.68）。尽管无法排除一些偏倚，但本荟萃分析支持以下观点：MDM2 SNP309基因是肺癌发生中的一个低外显率易感基因，且MDM2 SNP309与肺癌的关系在从不吸烟者中更强。
