1-磷酸鞘氨醇：一种动脉病变的调节因子。

Sphingosine 1-phosphate: a regulator of arterial lesions.

作者信息

Daum G, Grabski A, Reidy M A

机构信息

Department of Surgery, University of Washington, Seattle, WA, USA.

出版信息

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1439-43. doi: 10.1161/ATVBAHA.108.175240. Epub 2009 Jul 10.

DOI:10.1161/ATVBAHA.108.175240

PMID:19592471

Abstract

Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid that is critical in the development of blood vessels, and in the adult regulates vascular functions including vascular tone, endothelial integrity, and angiogenesis. Further, S1P may regulate arterial lesions in disease and after injury by controlling leukocyte recruitment and smooth muscle cell functions.

摘要

鞘氨醇-1-磷酸（S1P）是一种生物活性鞘脂，在血管发育中起关键作用，在成体中调节包括血管张力、内皮完整性和血管生成在内的血管功能。此外，S1P可能通过控制白细胞募集和平滑肌细胞功能来调节疾病和损伤后的动脉病变。