Ramsay R E, Slater J D
Department of Neurology, V. A. Medical Center, Miami, FL 33125.
Epilepsia. 1991;32 Suppl 6:S60-7. doi: 10.1111/j.1528-1157.1991.tb05894.x.
A hormone is an intrinsic substance carried via the blood to a target organ which is then functionally stimulated. Similar to extrinsically administered medications, the metabolism and function of the hormones may be altered by antiepileptic drugs (AEDs). The proposed mechanisms are (a) enhanced metabolism (natural steroids, synthetic steroids, e.g., decadron and birth control pills, thyroxine, and vitamin D3), (b) altered protein bonding (thyroxine, sex hormones), (c) impaired release into the systemic circulation (calcitonin, insulin, vitamin K clotting factors) and (d) altered end-organ effect. The AEDs most likely to interact with hormones are barbiturates, carbamazepine, and phenytoin.
激素是一种通过血液输送到靶器官并对其产生功能刺激的内源性物质。与外部给药的药物类似，抗癫痫药物（AEDs）可能会改变激素的代谢和功能。提出的机制包括：（a）代谢增强（天然类固醇、合成类固醇，如地塞米松和避孕药、甲状腺素和维生素D3）；（b）蛋白质结合改变（甲状腺素、性激素）；（c）释放到体循环中受损（降钙素、胰岛素、维生素K凝血因子）；以及（d）终末器官效应改变。最有可能与激素相互作用的抗癫痫药物是巴比妥类、卡马西平和苯妥英。
