Department of Nucleic Acid Biochemistry, Medical University of Lodz, 251 Pomorska Str., 92-213 Lodz, Poland.
Central Teaching Hospital of the Medical University of Lodz, 251 Pomorska Str., 92-213 Lodz, Poland.
Int J Mol Sci. 2020 Sep 11;21(18):6644. doi: 10.3390/ijms21186644.
Numerous studies have shown that vitamin D deficiency is very common in modern societies and is perceived as an important risk factor in the development of insulin resistance and related diseases such as obesity and type 2 diabetes (T2DM). While it is generally accepted that vitamin D is a regulator of bone homeostasis, its ability to counteract insulin resistance is subject to debate. The goal of this communication is to review the molecular mechanism by which vitamin D reduces insulin resistance and related complications. The university library, PUBMED, and Google Scholar were searched to find relevant studies to be summarized in this review article. Insulin resistance is accompanied by chronic hyperglycaemia and inflammation. Recent studies have shown that vitamin D exhibits indirect antioxidative properties and participates in the maintenance of normal resting ROS level. Appealingly, vitamin D reduces inflammation and regulates Ca level in many cell types. Therefore, the beneficial actions of vitamin D include diminished insulin resistance which is observed as an improvement of glucose and lipid metabolism in insulin-sensitive tissues.
大量研究表明，维生素 D 缺乏在现代社会中非常普遍，被认为是胰岛素抵抗和相关疾病（如肥胖症和 2 型糖尿病）发展的重要危险因素。虽然人们普遍认为维生素 D 是骨稳态的调节剂，但它对抗胰岛素抵抗的能力仍存在争议。本通讯的目的是综述维生素 D 降低胰岛素抵抗和相关并发症的分子机制。在本综述文章中，检索了大学图书馆、PUBMED 和 Google Scholar 以寻找相关研究进行总结。胰岛素抵抗伴随着慢性高血糖和炎症。最近的研究表明，维生素 D 具有间接的抗氧化特性，并参与维持正常的静止 ROS 水平。吸引人的是，维生素 D 可减轻炎症并调节许多细胞类型的 Ca 水平。因此，维生素 D 的有益作用包括降低胰岛素抵抗，这表现在改善胰岛素敏感组织的葡萄糖和脂质代谢方面。
